Evidence map›Paper›PMID 40480855›Full record

ReviewTrends in microbiology2025

A single-cell perspective on host-virus dynamics in the ocean.

Amir Fromm, Talia S Shaler, Frank O Aylward, Assaf Vardi

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amir FrommDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Talia S ShalerDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel.
Frank O AylwardDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA, USA; Center for Emerging, Zoonotic, and Arthropod-Borne Pathogens, Virginia Tech, Blacksburg, VA, USA 24061.
Assaf VardiDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, 7610001, Rehovot, Israel. Electronic address: assaf.vardi@weizmann.ac.il.

Funding

Coevolutionary Dynamics and Gene Exchange Between Nucleo-Cytoplasmic Large DNA Viruses and EukaryotesR35GM147290 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Frank O'Neill Aylward · 2022 to 2026
$1.9M
NIGMS NIH HHS R35 GM147290
6 · The paper itself

Abstract

Viral infections of marine microbes greatly impact ecological and biogeochemical processes. Typically, these host-virus interactions are studied at the population level using bulk transcriptomics, which presents a population-averaged perspective and masks diverse infection states. Recent advancements in single-cell technologies enable a simultaneous view of the virus and its host within a population and expose phenotypic heterogeneity during infection. We present a promising avenue for investigating marine viral ecology from a new single-cell perspective to reveal the viral life cycle and host antiviral strategies employed by rare resistant cells. Consequently, we can detect specific host-virus dynamics in the complex natural population, track the spread of infection across ecosystems, and study the ecological impact of marine viruses at an unprecedented resolution.

Indexed as

Aquatic OrganismsHost Microbial InteractionsHost-Pathogen InteractionsSeawaterSingle-Cell AnalysisVirusesVirus Physiological PhenomenaEcosystemOceans and Seasenvironmental ecologymarine microbesphenotypic heterogeneitysingle-cell transcriptomicsviral infection

Identifiers

PMID40480855
PMCPMC13182504

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.