Evidence map›Paper›PMID 40480833›Full record

ArticleRNA (New York, N.Y.)2025

Novel ADAR2 variants in children with seizures, intellectual disability, and motor delay have reduced RNA editing.

Qiupei Du, Anna Cherian, Raymond J Louie, Giulia Barcia, Natasha L Rudy, Rima Nabbout, Eugénie Sarda, Maelle Charpié, Wesley G Patterson, Liam P Keegan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qiupei DuCentral European Institute for Technology, Masaryk University, Brno 62500, Czechia.
Anna CherianCentral European Institute for Technology, Masaryk University, Brno 62500, Czechia.
Raymond J LouieGreenwood Genetic Center, Greenwood, South Carolina 29646, USA.
Giulia BarciaDepartment of Genetics, Necker Enfants Malades University Hospital, AP-HP, Université Paris Cité, 75015 Paris, France.
Natasha L RudyGreenwood Genetic Center, Greenwood, South Carolina 29646, USA.
Rima NabboutLaboratory of Translational Research for Neurological Disorders, UMR 1163 Institut National de la Santé et de la Recherche Médicale (INSERM), Imagine Institute, 75015 Paris, France.
Eugénie SardaDepartment of Pediatric Neurology, Reference Centre for Rare Epilepsies, Necker Enfants Malades University Hospital, AP-HP, Université Paris Cité, 75015 Paris, France.
Maelle CharpiéDepartment of Genetics, Necker Enfants Malades University Hospital, AP-HP, Université Paris Cité, 75015 Paris, France.
Wesley G PattersonGreenwood Genetic Center, Greenwood, South Carolina 29646, USA.
Liam P KeeganCentral European Institute for Technology, Masaryk University, Brno 62500, Czechia liam.keegan@ceitec.muni.cz mary.oconnell@ceitec.muni.cz.ORCID 0000-0001-7915-5790
Mary A O'ConnellCentral European Institute for Technology, Masaryk University, Brno 62500, Czechia liam.keegan@ceitec.muni.cz mary.oconnell@ceitec.muni.cz.ORCID 0000-0003-3844-6174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The

Indexed as

Adenosine DeaminaseIntellectual DisabilityMotor DisordersRNA-Binding ProteinsSeizuresChildChild, PreschoolComputer SimulationFemaleGene Expression RegulationHEK293 CellsHeLa CellsHumansInfantInfant, NewbornMaleADARB1 protein, humanAdenosine Deaminaseglutamate receptor ionotropic, AMPA 2Protein IsoformsReceptors, AMPARNA-Binding ProteinsADAR2ADARB1RNA editingseizures

Identifiers

PMID40480833
PMCPMC12360208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.