Evidence map›Paper›PMID 40480750›Full record

ArticleJACC. Case reports2025

From Normal to Zero Flow in 30 Seconds on HeartMate 3 LVAD: What Happened?

Jessica Schultz, Rebecca Cogswell, Lindsay Berger, Ranjit John, Andrew Shaffer, Valmiki Maharaj, Bhavadharini Ramu, Thenappan Thenappan, Tamas Alexy

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica SchultzDivision of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: schu3455@umn.edu.
Rebecca CogswellDivision of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Lindsay BergerM Health Fairview, University of Minnesota, Minneapolis, Minnesota, USA.
Ranjit JohnDivision of Cardiothoracic, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Andrew ShafferDivision of Cardiothoracic, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Valmiki MaharajDivision of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Bhavadharini RamuDivision of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Thenappan ThenappanDivision of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Tamas AlexyDivision of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe present a patient who acutely developed a zero flow alarm without warning signs almost 4 months after a HeartMate 3 (HM3) left ventricular assist device (LVAD) implantation. CASE SUMMARY: Patient was doing well as an outpatient when suddenly the zero flow alarm of his HM3 sounded without change in pump parameters. Patient progressed to cardiac arrest and did not survive. Autopsy concluded that his death was secondary to chronic heart failure, but industry analysis of the LVAD revealed impeller clot ingestion. DISCUSSION: Given the low incidence of pump thrombosis published with HM3, we present this case of ingested thrombus occurring without warning signs. Other LVAD parameters were normal at the time of the incident, despite the zero flow. TAKE-HOME MESSAGE: In an era when HM3 is the only durable LVAD available for de novo implant in the United States, we, as a community, need to better understand the true incidence of this complication and potential management options.

Indexed as

cardiac assist deviceschronic heart failurecomplicationthrombus

Identifiers

PMID40480750
PMCPMC12235148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.