Evidence map›Paper›PMID 40480675›Full record

ArticleBMJ open2025

External validation of risk prediction models for post-stroke mortality in Berlin.

Lukas Reitzle, Jessica L Rohmann, Tobias Kurth, Heinrich J Audebert, Marco Piccininni

Abstract readValidation StudyMulticenter Study
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lukas ReitzleDepartment of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany reitzlel@rki.de.ORCID http://orcid.org/0000-0001-7095-6567
Jessica L RohmannCenter for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Tobias KurthInstitute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-7169-2620
Heinrich J AudebertCenter for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Marco PiccininniCenter for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPrediction models for post-stroke mortality can support medical decision-making. Although numerous models have been developed, external validation studies determining the models' transportability beyond the original settings are lacking. We aimed to assess the performance of two prediction models for post-stroke mortality in Berlin, Germany.

designWe used data from the Berlin-SPecific Acute Treatment in Ischaemic or hAemorrhagic stroke with Long-term follow-up (B-SPATIAL) registry.

settingMulticentre stroke registry in Berlin, Germany.

participantsAdult patients admitted within 6 hours after symptom onset and with a 10th revision of the International Classification of Diseases discharge diagnosis of ischaemic stroke, haemorrhagic stroke or transient ischaemic attack at one of 15 hospitals with stroke units between 1 January 2016 and 31 January 2021. PRIMARY OUTCOME MEASURES: We evaluated calibration (calibration-in-the-large, intercept, slope and plot) and discrimination performance (c-statistic) of Bray

resultsFor the validation of Bray

conclusionsAmong Berlin stroke patients, both models showed good calibration performance for low and medium-risk patients and high discrimination while underestimating risk among high-risk patients. The acceptable performance of Bray

Indexed as

StrokeAgedAged, 80 and overBerlinFemaleHospital MortalityHumansMaleMiddle AgedRegistriesRisk AssessmentRisk FactorsClinical Decision-MakingMortalityPrognosisStroke

Identifiers

PMID40480675
PMCPMC12161359

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.