Evidence map›Paper›PMID 40480615›Full record

ArticleJournal of vascular surgery2025

Midterm outcomes from a 20-year experience treating functional popliteal artery entrapment syndrome in athletes.

John H Cabot, Lucy Yang, Chidyaonga Shalita, Arash Fereydooni, Mary Cain, Jason T Lee

Abstract read
In one paragraph

Article in Journal of vascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Short-term analysis of botulinum toxin A for functional popliteal artery entrapment syndrome.Journal of vascular surgery cases and innovative techniques · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John H CabotDivision of Vascular Surgery, Stanford School of Medicine, Palo Alto, CA; Stanford Cardiovascular Institute, Stanford Universtiy School of Medicine, Palo Alto, CA.
Lucy YangDivision of Vascular Surgery, Stanford School of Medicine, Palo Alto, CA.
Chidyaonga ShalitaDivision of Vascular Surgery, Stanford School of Medicine, Palo Alto, CA.
Arash FereydooniDivision of Vascular Surgery, Stanford School of Medicine, Palo Alto, CA; Stanford Cardiovascular Institute, Stanford Universtiy School of Medicine, Palo Alto, CA.
Mary CainDivision of Vascular Surgery, Stanford School of Medicine, Palo Alto, CA.
Jason T LeeDivision of Vascular Surgery, Stanford School of Medicine, Palo Alto, CA; Stanford Cardiovascular Institute, Stanford Universtiy School of Medicine, Palo Alto, CA; Baszucki Family Biobank, Division of Vascular Surgery, Stanford University School of Medicine, Palo Alto, CA. Electronic address: jtlee@stanford.edu.

Funding

T32 Training Program in Mechanisms and Innovation in Vascular DiseaseT32HL098049 · NHLBI · STANFORD UNIVERSITY · PI Nicholas James Leeper, Philip S Tsao · 2010 to 2026
$6.3M
Multi-Disciplinary Training Program in Cardiovascular Imaging at StanfordT32EB009035 · NIBIB · STANFORD UNIVERSITY · PI Koen Nieman, John M. Pauly · 2008 to 2026
$4.3M
NHLBI NIH HHS T32 HL098049NIBIB NIH HHS T32 EB009035
6 · The paper itself

Abstract

backgroundFunctional popliteal artery entrapment syndrome (FPAES) is a rare condition affecting young, active individuals presenting with claudication, swelling, or paresthesias, and often impairing athletic performance. Our standardized approach to this disease process involves testing with arterial duplex/digit plethysmography and provocative computed tomography angiography followed by surgical debulking consisting of popliteal artery release and resection of the anterolateral quadrant of the medial head of the gastrocnemius muscle and four-compartment fasciotomy. We sought to determine risk factors for clinical success vs recurrent symptoms in athletes undergoing surgery for FPAES.

methodsRetrospective review was conducted for consecutive athletes undergoing surgery for FPAES at a single institution. Demographics, preoperative symptoms, imaging findings, operative details, and postoperative outcomes were recorded, with primary outcome being return to prior level of sport, and secondary outcomes postoperative complications and long-term symptom recurrence.

resultsFrom 2005 to 2025, we operated on 125 limbs of 73 athletes. Most athletes competed at the collegiate level (38.4%), were female (64.5%), and had bilateral symptoms (84.2%). The most common sports represented were running (43.8%), soccer (26.0%), basketball (5.5%), lacrosse (5.5%), and water sports (5.5%). Surgical debulking was guided by computed tomography angiography compression of the gastrocnemius muscle and mean muscle volume resected was 6.86 cm

conclusionsFPAES is a rare yet impactful condition that limits athletes' ability to perform at high levels. This study represents the largest reported cohort to date, providing a 20-year experience of a standardized radiographic workup, symptom inventory, and definitive surgical treatment. Partial debulking of the medial head of the gastrocnemius after popliteal artery release is a safe and effective intervention, and when combined with concurrent fasciotomy seems to further improve outcomes. Male athletes seem to have improved outcomes with higher rates of return to sport and lower rates of symptom recurrence.

Indexed as

Arterial Occlusive DiseasesAthletesFasciotomyPopliteal ArteryVascular Surgical ProceduresAdolescentAdultComputed Tomography AngiographyConstriction, PathologicFemaleHumansMalePostoperative ComplicationsRecovery of FunctionRecurrenceRetrospective StudiesAthleteChronic exertional compartment syndromeFunctional popliteal entrapmentVascular compressive disorders

Identifiers

PMID40480615
PMCPMC12995344

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.