Evidence map›Paper›PMID 40480377›Full record

ReviewDiabetes research and clinical practice2025

Effect of type-2 diabetes mellitus in long-term mortality in older adults: The NEDICES cohort study.

A Corbatón-Anchuelo, S Vega-Quiroga, F Bermejo-Pareja, M Fuentes-Ferrer, M Álvarez-González, J Benito-León, F Hawkins-Carranza, M Serrano-Ríos

Abstract readReview
In one paragraph

Review in Diabetes research and clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A Corbatón-AnchueloSpanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain; Cardiovascular Risk Group, Research Institute of Clínico San Carlos University Hospital (IdISSC), Madrid, Spain. Electronic address: arturocorbaton@yahoo.es.
S Vega-QuirogaPrimary Care of Castilla & León Autonomous Community, Sacyl, Spain.
F Bermejo-ParejaNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain; Research Institute University Hospital 12 de Octubre (I+12), Madrid, Spain.
M Fuentes-FerrerResearch Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
M Álvarez-GonzálezGerencia de Asistencia Sanitaria de Segovia (GASSE), Sacyl, Spain.
J Benito-LeónNetwork Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain; Research Institute University Hospital 12 de Octubre (I+12), Madrid, Spain; Neurology Department, University Hospital, 12 de Octubre, Madrid, Spain; Department of Medicine, Complutense University, Madrid, Spain.
F Hawkins-CarranzaResearch Institute University Hospital 12 de Octubre (I+12), Madrid, Spain; Department of Medicine, Complutense University, Madrid, Spain.
M Serrano-RíosSpanish Academy of Medicine, Madrid, Spain (Deceased April 2021).

Funding

ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORR01NS039422 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2000 to 2013
$7.7M
NINDS NIH HHS R01 NS039422
6 · The paper itself

Abstract

aimsTo describe the mortality associated with type-2 diabetes mellitus (T2DM) in a Spanish elderly population during a 22-year period. PROCEDURES: Prospective follow-up study (1994-95 to 2017) including 4,998 individuals (≥65 years old at baseline) of three communities (one rural) from central Spain. T2DM diagnosis was recorded during a clinical interview in 1994-95 (self-reported and information from their doctors, including treatment). Mortality incidence until 2017 was checked.

resultsA total of 4,038 subjects were included, with a mean age of 73.6 (±6.6) years; 1,718 (42.5 %) were male and 685 (17.0 %) were diagnosed with T2DM. The mortality rate during follow-up was 85.2 %. Cardiovascular disease was the most frequent cause of death in DM2 subjects, followed by neoplasm. The mortality hazard ratio found for T2DM compared to non-T2DM subjects was 1.29 (1.16-1.45) after adjusting for multiple risk factors. The effect of TDM2 on the mortality rate remained significant in men (HR:1.27; CI 95 %:1.08-1.49;p = 0.005) and women (HR:1.32; CI 95 %:1.14-1.53;p < 0.001), with no differences between sexes (p = 0.705). MAIN

conclusionThe sustained reduction in T2DM elderly Spanish subjects' life expectancy address the necessity of community interventions and campaigns regarding lifestyle modifications and reinforce the need for an adequate and regular TDM2 subjects clinical follow-up.

Indexed as

Diabetes Mellitus, Type 2AgedAged, 80 and overCardiovascular DiseasesCohort StudiesFemaleFollow-Up StudiesHumansMaleProspective StudiesRisk FactorsSpainElderlyLong-term mortalityT2DM (type 2 diabetes mellitus)

Identifiers

PMID40480377
PMCPMC12335756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.