Evidence map›Paper›PMID 40480300›Full record

ArticleThe American journal of the medical sciences2025

Elevated blood anandamide levels in acute COVID-19 pneumonia with respiratory failure.

Abhishek Basu, Lenny Pommerolle, Muhammad Arif, Angelo Y Meliton, Inemesit Udofia, David Wu, Gökhan M Mutlu, Bernadette R Gochuico, Ross Summer, Ayodeji Adegunsoye and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of the medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abhishek BasuSection on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.
Lenny PommerolleSection on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.
Muhammad ArifSection on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.; Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.
Angelo Y MelitonSection of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA.
Inemesit UdofiaSection of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA.
David WuDepartment of Pulmonology, The Permanente Medical Group, Kaiser Permanente, Oakland, CA, USA.
Gökhan M MutluSection of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA.
Bernadette R GochuicoSection on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Ross SummerDivision of Pulmonary, Allergy & Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
Ayodeji AdegunsoyeSection of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA.
Ellen L BurnhamDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, CO, USA.
Resat CinarSection on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.. Electronic address: resat.cinar@nih.gov.

Funding

Supplement: CoPARC: Colorado Pulmonary Alcohol Research CollaborativeR24AA019661 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI ELLEN L BURNHAM · 2011 to 2026
$8.5M
Fibroproliferative mechanisms in organ fibrosisZIAAA000355 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI CINAR, RESAT · 2021 to 2025
$6.6M
Improving Pulmonary Fibrosis Classification with Genomics Informed Phenotypic ClustersK23HL146942 · NHLBI · UNIVERSITY OF CHICAGO · PI ADEGUNSOYE, AYODEJI · 2020 to 2024
$810k
Impact of Alcohol Misuse on Cognitive and Respiratory Outcomes in COVID-19-associated Acute Respiratory FailureR01AA029855 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI BURNHAM, ELLEN L · 2021 to 2023
$727k
Intramural NIH HHS ZIA AA000355NHLBI NIH HHS K23 HL146942NIAAA NIH HHS R01 AA029855NIAAA NIH HHS R24 AA019661
6 · The paper itself

Abstract

backgroundSubsets of COVID-19 pneumonia patients with acute respiratory failure experienced long-term respiratory dysfunction and persistent radiological abnormalities. However, mechanisms contributing to persistent pulmonary dysfunction following COVID-19 remain unclear. Increased cannabinoid receptor 1 (CB

methodsIn this study, we sought to determine the relationship between circulating endocannabinoids and inflammatory mediators in patients with COVID-19 pneumonia from two independent cohorts in different geographic US locations. Endocannabinoid levels were measured using liquid chromatography coupled triple quadrupole mass spectrometry, while inflammatory cytokines and chemokines were measured using Luminex assay in blood serum collected at various time points during COVID-19 pneumonia.

resultsWe found that blood serum levels of endocannabinoid AEA were significantly elevated in acute COVID-19 pneumonia patients compared to patients with non-COVID-19-associated acute respiratory failure, and healthy controls. Further, 2-arachidonyl glycerol (2AG)] was significantly elevated in acute COVID-19 pneumonia patients on par with non-COVID acute respiratory failure patients. Levels of circulating AEA and 2AG correlated with multiple inflammatory markers.

conclusionsOur findings suggest increased circulating endocannabinoid tone may be involved in the pathogenesis of COVID-19 pneumonia during the acute phase of illness.

Indexed as

Arachidonic AcidsCOVID-19EndocannabinoidsPolyunsaturated AlkamidesRespiratory InsufficiencyAdultAgedCytokinesFemaleHumansMaleMiddle AgedSARS-CoV-2anandamideArachidonic AcidsCytokinesEndocannabinoidsPolyunsaturated AlkamidesAnandamideARDSBlood biomarkerCB(1)RCOVID-19EndocannabinoidsFVCPulmonary functionRespiratory failureSARS-CoV-2

Identifiers

PMID40480300
PMCPMC12212345

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.