Evidence map›Paper›PMID 40480241›Full record

ArticleThe lancet. Diabetes & endocrinology2025

Reversal of congenital hypogonadotropic hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation.

Régis Coutant, Nadia Zaegel, Frédéric Illouz, Lucie Levaillant, Françoise Magnin, Julie Perrot, Abd El Kader Ait Tayeb, Claire Briet, Ursula B Kaiser, Jérôme Bouligand and 2 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in The lancet. Diabetes & endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Reversal of Congenital Hypogonadotropic Hypogonadism.The Journal of clinical endocrinology and metabolism · 2026
    Pooled it
  2. Genetics of Idiopathic Hypogonadotropic HypogonadismJournal of clinical research in pediatric endocrinology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Régis CoutantDepartment of Pediatric Endocrinology, Reference Center for Rare Pituitary Diseases (CRMR-HYPO), Angers University Hospital, Angers, France.
Nadia ZaegelParis-Saclay University, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Department of Endocrinology and Reproductive Diseases, Reference Center for Rare Pituitary Diseases (CRMR-HYPO), Paris 94275, France; INSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France.
Frédéric IllouzDepartment of Endocrinology, Diabetology and Nutrition, Reference Center for Rare Pituitary Diseases HYPO, Angers University Hospital, Angers, France.
Lucie LevaillantDepartment of Pediatric Endocrinology, Reference Center for Rare Pituitary Diseases (CRMR-HYPO), Angers University Hospital, Angers, France.
Françoise MagninINSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France.
Julie PerrotINSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France.
Abd El Kader Ait TayebINSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France; Department of Endocrinology, Diabetology and Nutrition, Reference Center for Rare Pituitary Diseases HYPO, Angers University Hospital, Angers, France; Paris-Saclay University, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Department of Molecular Genetics, Pharmacogenomics, and Hormonology, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Paris, France.
Claire BrietDepartment of Endocrinology, Diabetology and Nutrition, Reference Center for Rare Pituitary Diseases HYPO, Angers University Hospital, Angers, France.
Ursula B KaiserDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jérôme BouligandINSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France; Department of Endocrinology, Diabetology and Nutrition, Reference Center for Rare Pituitary Diseases HYPO, Angers University Hospital, Angers, France; Paris-Saclay University, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Department of Molecular Genetics, Pharmacogenomics, and Hormonology, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Paris, France.
Jacques YoungParis-Saclay University, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Department of Endocrinology and Reproductive Diseases, Reference Center for Rare Pituitary Diseases (CRMR-HYPO), Paris 94275, France; INSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France.
Luigi MaioneParis-Saclay University, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Department of Endocrinology and Reproductive Diseases, Reference Center for Rare Pituitary Diseases (CRMR-HYPO), Paris 94275, France; INSERM UMRS-1185 PHYSENDO, Physiologie et Physiopathologie Endocriniennes, Paris, France. Electronic address: luigi.maione@aphp.fr.

Funding

Deciphering the functional role of MKRN3 in puberty and reproductionR01HD082314 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI Ursula B. Kaiser · 2015 to 2026
$5.7M
NICHD NIH HHS R01 HD082314
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40480241
PMCPMC13268719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.