Evidence map›Paper›PMID 40480220›Full record

ArticleImmunity2025

Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy.

Jesse Garcia Castillo, Sebastian Fernandez, Timothy Campbell, Diego Gonzalez Ventura, Jacob Williams, Julia Ybarra, Nicole Flores Hernandez, Elina Wells, Daniel A Portnoy, Michel DuPage

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Avoidance of MAIT cells is an essential determinant ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Article
  7. Infection and immunity · 2025
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jesse Garcia CastilloDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Sebastian FernandezDepartment of Plant and Microbiology, University of California, Berkeley, Berkeley, CA 94720, USA.
Timothy CampbellDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Diego Gonzalez VenturaDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Jacob WilliamsDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Julia YbarraDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Nicole Flores HernandezDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Elina WellsDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Daniel A PortnoyDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Plant and Microbiology, University of California, Berkeley, Berkeley, CA 94720, USA.
Michel DuPageDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dupage@berkeley.edu.

Funding

The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI PORTNOY, DANIEL A · 2004 to 2025
$45.5M
Listeria Hemolysis and Escape From a VacuoleR01AI027655 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DANIEL A PORTNOY · 1993 to 2026
$10.1M
Engineering precision cancer immunotherapyDP2CA247830 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUPAGE, MICHEL · 2019 to 2019
$2.4M
Reversing cancer immunosuppression using attenuated Listeria monocytogenesR01CA283604 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Michel DuPage, DANIEL A PORTNOY · 2024 to 2026
$1.4M
The UC Berkeley MARC: Shaping the Next Generation of Scientific LeadersT34GM145535 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Ellen A Lumpkin · 2022 to 2026
$839k
NCI NIH HHS DP2 CA247830NCI NIH HHS R01 CA283604NIAID NIH HHS P01 AI063302NIAID NIH HHS R01 AI027655NIGMS NIH HHS T34 GM145535
6 · The paper itself

Abstract

Bacteria engineered to express tumor antigens as cancer vaccines have produced mixed results. Here, we used an attenuated strain of Listeria monocytogenes (ΔactA, Lm) that lacks tumor antigens to examine the immune response to Lm itself in tumor-bearing mice following intravenous (i.v.), intratumoral (i.t.), or combined i.v. + i.t. Lm delivery. Unexpectedly, i.t. Lm alone recruited neutrophils to tumors, which became immunosuppressive, provided an intracellular reservoir for long-term persistence of Lm in tumors, and promoted tumor growth. In contrast, prior i.v. Lm administration generated anti-Lm cytotoxic CD8

Indexed as

Cancer VaccinesCD8-Positive T-LymphocytesImmunotherapyListeria monocytogenesNeoplasmsAnimalsAntigens, NeoplasmApoptosisCell Line, TumorCross-PrimingFemaleHumansMiceMice, Inbred C57BLNeutrophilsAntigens, NeoplasmCancer Vaccinesadaptive immunitybacterial immunotherapyimmunotherapiesinfectious diseasetumor immunology

Identifiers

PMID40480220
PMCPMC12893775

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.