ArticleMolecular cell2025
Finding a foothold to fight: New insights into the viral RNA sensing and activation mechanism of OAS2.
Article in Molecular cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oligoadenylate synthetases (OASs) are a family of double-stranded RNA (dsRNA)-activated nucleotidyltransferases involved in pathogen sensing and innate immune response. In this issue of Molecular Cell, Merold et al. define a mechanism of OAS2 activation by dsRNA-length discrimination and its deficiency associated with autoimmune disorder.
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