Evidence map›Paper›PMID 40479945›Full record

ReviewCurrent opinion in immunology2025

Emerging role of follicular regulatory T-cells in neuroimmunological disorders.

Stephen Opoku, Qisen Guo, Jianmei W Leavenworth

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephen OpokuDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA; Graduate Biomedical Sciences Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Qisen GuoDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA; Graduate Biomedical Sciences Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jianmei W LeavenworthDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; The O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: jleavenworth@uabmc.edu.

Funding

Contribution of the effector Treg-B-antibody nexus to the regulation of CNS autoimmunityR01AI148711 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEAVENWORTH, JIANMEI WU · 2020 to 2024
$2.2M
Follicular Regulatory T-cells Promote CancerR01CA276190 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianmei Wu Leavenworth · 2023 to 2026
$1.5M
Hijacking the Blimp1-Neuritin Axis to Promote Cancer by Follicular Regulatory T-cellsR21CA278853 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEAVENWORTH, JIANMEI WU · 2023 to 2024
$373k
NCI NIH HHS R01 CA276190NCI NIH HHS R21 CA278853NIAID NIH HHS R01 AI148711
6 · The paper itself

Abstract

Immune tolerance is essential for preventing self-damage while maintaining effective immune responses against foreign insults. Disruptions in this balance contribute to autoimmune and inflammatory conditions, including neuroimmunological disorders that are characterized by aberrant inflammation in the nervous system. Follicular regulatory T (T

Indexed as

T-Lymphocytes, RegulatoryAnimalsHumansImmune Tolerance

Identifiers

PMID40479945
PMCPMC12276905

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.