ArticleThe journal of physical chemistry. B2025
A Trade-off between Force and Flow May Lead to Reduced Entropy Production Rate during Faster Microbial Growth.
Article in The journal of physical chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- An Acetyl-CoA-Gated Metabolic Checkpoint Links Precursor Supply to Cordycepin Biosynthesis inCurrent issues in molecular biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thermodynamics dictates that the entropy production rate (EPR) of a steady-state isothermal chemical reaction network rises with reaction rates. Living cells can, in addition, alter reaction rates by changing enzyme concentrations, giving them control over metabolic activities. Here, we ask whether microbial cells can break this relation between EPR and reaction rates by shifting to a metabolism with lower thermodynamic driving force (per unit of biomass) at faster growth. First, we study an example metabolic network to illustrate that maximization of metabolic flux by optimal allocation of resources can indeed lead to selection of a pathway with a lower driving force. This pathway then compensates for the reduction in driving force by relying on fewer enzymes with sufficiently increased concentrations, resulting in a higher flux. Next, we investigate the EPR per unit biomass of microbes that change their catabolic network as a function of their growth rate, using three models for chemostat cultivation of the yeast
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.