ReviewChemical reviews2025
Metal-N-Heterocyclic Carbene Complexes in Buchwald-Hartwig Amination Reactions.
Review in Chemical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Substituent Effects on the Stability of Pd-NHC Complexes: Switching From Molecular to "Cocktail-Type" Catalysis.Journal of computational chemistry · 2026Article
- Carbenylative Buchwald-Hartwig Coupling of Aryl Halides, N-Tosylhydrazones, and Anilines.Journal of the American Chemical Society · 2026Article
- Palladium-catalyzed Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions towards the synthesis of pharmacologically potent pyrimidine-based molecules.Molecular diversity · 2026Review
- Oxidant-free Au(I)/Au(III) catalysis: Rational development of hemilabile proximity-guided N-heterocyclic carbenes.Science advances · 2026Article
- IPr*Dalton transactions (Cambridge, England : 2003) · 2026Article
- Bridged Pyrroloindole-CAYC-Gold Complexes: Harnessing Weak Secondary Intramolecular Au···H-C(spAngewandte Chemie (International ed. in English) · 2026Article
- Bidentate bis(NHC-carboxylate) palladium and nickel complexes for the hydrosilylative reduction of carbonyl compounds.RSC advances · 2026Article
- Selectivity for Exhaustive Cross-Coupling of Dihaloarenes is Affected by the Interplay Between Halide Byproduct, Solvent, and Ligand.Organometallics · 2026Article
- Skeletal Editing of Alkenes with Nitroarenes via Photoinduced Rearrangement of N─O═C Dipoles Forms Lactams and Amides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
We present a comprehensive overview of the Buchwald-Hartwig amination, one of the most useful methods for C-N bond formation, mediated by NHC-transition-metal-complexes, covering the literature since 1999 (the first report on Buchwald-Hartwig amination by Nolan et al.) through December 2024. Palladium- and nickel-N-heterocyclic carbene (NHC) complexes are key contributors to Buchwald-Hartwig amination and are thoroughly discussed in this review, along with examples of cobalt and rhodium-NHC complexes. Apart from the conventional aryl/alkyl amines and aryl halides coupling, participation of versatile and challenging functional groups like pseudohalides, amides, ester, sulfoxides, unactivated aryl sulfamates, carbamates, pivalates, as well as novel electrophiles, such as aryl fluorides, methyl ethers, and silyloxyarenes, are also presented. The Reader is provided with an overview of the key role of metal-NHC complexes, their crucial role in constructing carbon-nitrogen bonds, and their importance in medicinal and materials chemistries as well as in drug discovery.
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