ArticlePloS one2025
Physiological and psychological responses to five-day fasting.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Bidirectional influences and clinical implications of psychological factors and oral health during orthodontic treatment.The Saudi dental journal · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to examine the variations in adipokines, myokines, inflammation indicators, glucose, insulin, and ketones in the body over a 5-day fasting period. Additionally, the study aimed to investigate the underlying factors contributing to changes in body mass index (BMI) and fat mass. These factors included blood markers, participants' healthy lifestyle habits, emotional intelligence, personality traits, impulsivity, overall well-being, and subjective happiness. The study involved 42 women with an average age of 49.8 years (± 9.3 years). The following indicators were measured: leptin, adiponectin, TNF-alpha, BDNF, irisin, IL-6, insulin, glucose levels, and ketone bodies. Various assessments were utilized, including the Physical Activity Questionnaire, the Brunel Mood Scale (BRUMS-LTU), the Schutte Self-Report Emotional Intelligence Test, the 10-item Perceived Stress Scale, and the Big Five personality traits. The results showed that fasting led to substantial reductions in body mass, waist circumference, leptin levels, glucose, and insulin levels, while simultaneously increasing ketone bodies. Basal energy expenditure decreased, but participants experienced improvements in mood, with increased vigor and reduced tension. Although markers of inflammation rose, the concentration of irisin declined, while levels of BDNF and adiponectin remained unchanged. Moreover, a greater reduction in fat mass was associated with higher pre-fasting well-being, emotional intelligence, and lower levels of tension and impulsivity. Conversely, the loss of lean mass was linked to neuroticism and higher levels of impulsivity, particularly concerning pre-fasting tension levels.These findings suggest that psychological factors may impact fasting outcomes, emphasizing the need for personalized fasting strategies.
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Registered trials
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