ArticleJCO precision oncology2025
Validation of a 15-Gene Prognostic Signature in Metastatic Clear Cell Renal Cell Carcinoma.
Article in JCO precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
purposeWe previously developed and validated a 15-gene prognostic signature (15G score) in localized clear cell renal cell carcinoma (ccRCC). Given its ability to differentiate aggressive and indolent disease, we sought to apply the 15G score to patients with metastatic ccRCC to evaluate its prognostic performance in this setting.
methodsWe analyzed 2,121 patients from four major metastatic ccRCC trial data sets: IMmotion 151 (
resultsA high 15G score was associated with significantly worse PFS in four of the six treatment groups: atezolizumab plus bevacizumab, sunitinib, atezolizumab, and everolimus (hazard ratios [HRs], 1.7 [95% CI, 1.4 to 2.2], 1.7 [1.4-2.0] 2.8, [95% CI, 1.6 to 4.9], and 1.5 [95% CI, 1.1 to 2.2], respectively; all
conclusionThe 15G score was independently prognostic in metastatic ccRCC among patients receiving different systemic therapy regimens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.