Evidence map›Paper›PMID 40479592›Full record

ArticleOrganic letters2025

Total Syntheses of Stereoisomeric Congeners of Rufomycin Natural Products Having Anti-Mycobacterial Activity.

Fan Fei, Shichun Lun, Alexander Pacheco, William R Bishai, Jason K Sello

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fan FeiDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, United States.ORCID 0009-0003-5736-0509
Shichun LunCenter for Tuberculosis Research, Department of Medicine, Division of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, Maryland 21231-1044, United States.
Alexander PachecoDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, United States.
William R BishaiCenter for Tuberculosis Research, Department of Medicine, Division of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, Maryland 21231-1044, United States.
Jason K SelloDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, United States.ORCID 0000-0001-6263-7902

Funding

Glutamine metabolism inhibitors for TB and TB-HIV: dual action as host-directed therapies with antibacterial activityR01AI155602 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 2020 to 2024
$4.0M
Studies of the Antibacterial Activity of and Resistance to Molecules Targeting the ClpP PeptidaseR01AI123400 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SELLO, JASON K · 2017 to 2021
$2.9M
NIAID NIH HHS R01 AI123400NIAID NIH HHS R01 AI155602
6 · The paper itself

Abstract

Syntheses of bioactive rufomycin natural product congeners that differ in stereochemistry at a conserved methyl-substituted amino-hydroxy-piperidone (Ahp) moiety have been achieved for the first time. In addition to gaining new insights into the formation and conformation of the Ahp stereoisomers, we were intrigued to find that theirs reduction improves rufomycin bioactivity significantly.

Indexed as

Anti-Bacterial AgentsAntitubercular AgentsBiological ProductsPiperidonesMolecular StructureStereoisomerismAnti-Bacterial AgentsAntitubercular AgentsBiological ProductsPiperidones

Identifiers

PMID40479592
PMCPMC12186687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.