ReviewAging and disease2025
RSV Infection and Neurodegenerative Diseases: A Hypothesis of Energy Metabolism Disruption via the Lung-Brain Axis.
Review in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory Syncytial Virus (RSV), primarily recognized as a respiratory pathogen, has emerged as a potential contributor to neurodegenerative diseases via the "lung-brain axis." Preclinical studies highlight RSV-induced energy metabolism dysfunction as a core pathological mechanism encompassing mitochondrial dysfunction, glucose metabolism reprogramming, and microglial metabolic polarization-critical gaps in clinical validation, molecular specificity, and translational relevance. This review addresses these limitations by advocating for enhanced epidemiological research, detailed molecular pathway characterization, and the integration of human-relevant models. Targeted metabolic interventions have been proposed, supported by recent mechanistic insights, to bridge the gap between hypotheses and therapeutic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.