ArticleCancer2025
Racial and ethnic variation in body composition and prognosis of nonmetastatic breast cancer.
Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Future of CT body composition research: Methodological discrepancies and advances.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Review
- Artificial intelligence standardizes CT-based body composition analysis in breast cacer to address methodological heterogeneity.Frontiers in oncology · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe disproportionate burden of obesity among Black women may contribute to disparities in breast cancer survival; yet, associations of body mass index (BMI), a proxy for total adiposity, are inconsistent.
methodsTo examine racial/ethnic differences in body composition and evaluate associations with breast cancer-specific and all-cause mortality, this study identified 3898 women 18 to <90 years old, diagnosed in 2005-2019 with stage II-III breast cancer at Kaiser Permanente Northern California. The authors measured subcutaneous, visceral, and intermuscular adipose tissue area from computed tomography scans.
resultsBody composition differed by race: compared to other race/ethnicity groups, Black women had higher skeletal muscle and subcutaneous adipose, but lower visceral adipose tissues, whereas Asian/Pacific Islander women had lower intermuscular and subcutaneous adipose tissue. BMI was not significantly associated with mortality in any group. Among Black women, higher subcutaneous adipose tissue was associated with breast cancer-specific mortality (hazard ratio [HR], 1.24; 95% confidence interval [CI], 1.02-1.52) and all adipose tissue measures were associated with increased all-cause mortality (intermuscular HR, 1.26; 95% CI, 1.09-1.46; subcutaneous HR, 1.25; 95% CI, 1.05-1.48; and visceral HR, 1.32; 95% CI, 1.03-1.68, respectively). By contrast, only increased intermuscular adipose tissue was associated with all-cause mortality among White women (HR, 1.08; 95% CI, 1.00-1.16), with null associations for Hispanic and Asian/Pacific Islander women.
conclusionsBMI obscures variation in body composition, particularly for Black women, who have more subcutaneous adipose and skeletal muscle but less visceral adipose tissue at higher BMIs. These findings from routine imaging highlight opportunities for tailored lifestyle interventions to improve survivorship and mitigate disparities.
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