ArticleScience advances2025
Lipid droplet-enriched luminogens enable adoptive macrophage transfer for treatment of bacterial sepsis.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Review
- Cell-based drug delivery for combating bacteria: focus on refractory infections.Journal of nanobiotechnology · 2026Review
- Advances in immune cell-based therapeutic agents for the treatment of inflammation-related diseases.Acta pharmaceutica Sinica. B · 2026Review
- Microbial medicines: Unlocking the therapeutic potential of the microbiome in cancer treatment.Journal of controlled release : official journal of the Controlled Release Society · 2026Review
- Research advances on the gut-kidney axis theory in sepsis-associated acute kidney injury.Frontiers in pharmacology · 2026Review
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial sepsis, a life-threatening systemic inflammatory response to infection affecting over 30 million people annually, is exacerbated by antibiotic resistance and immune suppression. Here, we report a small luminescent molecule, TPA2PyPh, as a potent antibacterial agent and its potential for lipid droplet-engineered macrophage transfer strategy in treating bacterial sepsis. Engineered macrophages, created by directly incubating TPA2PyPh with macrophages, enabled the luminogen to precisely bind to intracellular lipid droplets. Upon engulfment of bacteria, these TPA2PyPh-loaded macrophages use natural lipid uptake mechanisms to deliver the luminogen to intracellular bacteria, disrupting their membranes and inserting into the bacterial DNA, thereby inducing bacterial elimination. Our findings show that the adoptive transfer of TPA2PyPh-loaded macrophages substantially diminishes bacterial burden in septic mice and substantially reduces mortality rates. This study demonstrates the potential of TPA2PyPh as an effective antibacterial agent and supports the use of adoptive lipid droplet-engineered macrophage transfer as an effective approach for treating sepsis and managing severe infectious diseases.
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Registered trials
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