Evidence map›Paper›PMID 40479053›Full record

ArticleScience advances2025

HOPS-dependent vesicle tethering lock inhibits endolysosomal fusions and autophagosome secretion upon the loss of Syntaxin17.

Dávid Hargitai, Anikó Nagy, Iván Bodor, Győző Szenci, Hajnalka Laczkó-Dobos, Arindam Bhattacharjee, Natali Neuhauser, Szabolcs Takáts, Gábor Juhász, Péter Lőrincz

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dávid HargitaiDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID 0000-0002-6064-9966
Anikó NagyDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID 0000-0002-0979-1617
Iván BodorDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID 0009-0004-9087-9721
Győző SzenciDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID 0000-0003-0359-6869
Hajnalka Laczkó-DobosInstitute of Genetics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary.ORCID 0009-0007-9976-6020
Arindam BhattacharjeeInstitute of Genetics, HUN-REN Biological Research Centre Szeged, Szeged, Hungary.ORCID 0000-0002-8399-3292
Natali NeuhauserDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.
Szabolcs TakátsDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID 0000-0003-2139-7740
Gábor JuhászDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID 0000-0001-8548-8874
Péter LőrinczDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary.ORCID 0000-0001-7374-667X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The autophagosomal SNARE (soluble

Indexed as

AutophagosomesDrosophila ProteinsEndosomesLysosomesMembrane FusionQa-SNARE ProteinsAnimalsAutophagyDrosophila melanogasterSalivary GlandsDrosophila ProteinsQa-SNARE Proteins

Identifiers

PMID40479053
PMCPMC12143387

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.