Evidence map›Paper›PMID 40479045›Full record

ArticleScience advances2025

The SH protein of mumps virus is a druggable pentameric viroporin.

Kira Devantier, Trine L Toft-Bertelsen, Andreas Prestel, Viktoria M S Kjær, Cagla Sahin, Marco Giulini, Stavroula Louka, Katja Spiess, Asmita Manandhar, Katrine Qvortrup and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. The 6-kilodalton peptide 1 of the familyFrontiers in microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kira DevantierLaboratory for Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0009-0002-4200-4707
Trine L Toft-BertelsenDepartment of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Andreas PrestelStructural Biology and NMR Laboratory (SBiNLab), The Linderstrøm-Lang Centre for Protein Science and Integrative Structural Biology at University of Copenhagen (ISBUC), Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5459-9608
Viktoria M S KjærLaboratory for Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5463-2324
Cagla SahinBiomedical Mass Spectrometry and Systems Biology, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-2889-5200
Marco GiuliniDepartment of Chemistry, Faculty of Science, Computational Structural Biology Group, Bijvoet Centre for Biomolecular Research, Utrecht 3584 CS, Netherlands.ORCID 0000-0002-2691-712X
Stavroula LoukaDepartment of Chemistry, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Katja SpiessLaboratory for Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2388-4617
Asmita ManandharDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Katrine QvortrupDepartment of Chemistry, Technical University of Denmark, DK-2800 Lyngby, Denmark.ORCID 0000-0003-3828-2069
Trond UlvenDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-8135-1755
Bo H BentzenDepartment of Biomedical Sciences, University of Copenhagen, Denmark.
Alexandre Mjj BonvinDepartment of Chemistry, Faculty of Science, Computational Structural Biology Group, Bijvoet Centre for Biomolecular Research, Utrecht 3584 CS, Netherlands.ORCID 0000-0001-7369-1322
Nanna MacAulayDepartment of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7800-6600
Birthe B KragelundStructural Biology and NMR Laboratory (SBiNLab), The Linderstrøm-Lang Centre for Protein Science and Integrative Structural Biology at University of Copenhagen (ISBUC), Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7454-1761
Mette M RosenkildeLaboratory for Molecular and Translational Pharmacology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-9600-3254

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral infections are on the rise and drugs targeting viral proteins are needed. Viroporins constitute a growing group of virus-encoded transmembrane oligomeric proteins that allow passage of small molecules across the membrane. Despite sparsity in viroporin structures, recent work has revealed diversity in both the number of transmembrane helices and oligomeric states. Here, we provide evidence that the small hydrophobic protein (SH) from mumps virus is a pentameric viroporin. From extensive biophysical data, a HADDOCK model of full-length SH shows its intracellular C-terminal region to form an extended structure crucial to stabilization of the pentamer. Heterologous expression of wild-type SH and variants in

Indexed as

Mumps virusViral ProteinsViroporin ProteinsAnimalsAntiviral AgentsHumansModels, MolecularOocytesProtein MultimerizationXenopus laevisAntiviral AgentsViral ProteinsViroporin Proteins

Identifiers

PMID40479045
PMCPMC12143350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.