ArticlePloS one2025
Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- From Neuroadaptation to Neuroprogression: Rethinking Chronic Cocaine Exposure Through a Model of Cocaine-Related Cerebropathy.Journal of clinical medicine · 2026Article
- Substance Use Disorders and the Psychosis Spectrum: Assessment, Clinical Challenges and Management.Journal of clinical medicine · 2026Review
- Prehabilitation Reimagined as Policy: A Multidimensional Framework to Reduce Pain, Opioid Use, and Surgical Risk.International journal of spine surgery · 2025Article
- Sex-dependent role of hippocampal BDNF and GSK-3β in mediating PTSD-like behaviors in both sexes of adolescent rats exposed to fear conditioning, extinction, and reinstatement.Experimental brain research · 2025Article
- Correction: Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats.PloS one · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCocaine abuse and Cocaine Use Disorder (CUD) is an increasingly urgent public health issue leading to major health risks often resulting in a decreased lifespan and quality of life. Previous human research has described brain function of cocaine addicts however the amount of cocaine use, duration of use, and exclusion of using other drugs (i.e., nicotine and alcohol) have all been difficult to control. One unanswered question is related to how does cocaine affect both brain glucose metabolism and functional connectivity?.
methodsThe present study examined using positron emission tomography (PET) imaging and the glucose analog [18F]-Fluorodeoxyglucose (18F-FDG), brain glucose metabolism (BGluM) and functional connectivity in male rats (N = 6) that self-administered cocaine compared to baseline control scans in the same animals prior to cocaine exposure.
resultsOur Results showed that Cocaine Self-Administration (CSA) caused significant BGluM decreases in several brain regions including posterior thalamic nuclei, Claustrum (Cl); Solitary nucleus, Presubiculum (PrS); Caudate Putamen (CPu); Anterior hypothalamic area (AHA); Ventral pallidum (VP); and amygdala. Activation (increased BGluM) was observed in the primary somatosensory cortex. These regions are associated with memory, spatial navigation, visual processing and saliency along with other somatosensory and motor functions, as well as regulatory autonomic function (cardiovascular) and hormonal response.
conclusionThis brain functional connectivity mapping illustrated a brain circuit composed of brain regions that are either a part of or connect with the mesolimbic reward pathway that is mediated by dopamine. When this circuit is dysregulated, it is believed to be associated with substance use disorders and reward dysregulation which have recently been described as attributes of preaddiction.
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