Evidence map›Paper›PMID 40478890›Full record

ArticleeLife2025

A general mechanism for initiating the bacterial general stress response.

Rishika Baral, Kristin Ho, Ramasamy P Kumar, Jesse B Hopkins, Maxwell B Watkins, Salvatore LaRussa, Suhaily Caban-Penix, Logan A Calderone, Niels Bradshaw

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The roles and synthesis of inorganic polyphosphate inbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rishika BaralDepartment of Biochemistry, Brandeis University, Waltham, United States.ORCID https://orcid.org/0000-0002-9365-8877
Kristin HoDepartment of Biochemistry, Brandeis University, Waltham, United States.
Ramasamy P KumarDepartment of Biochemistry, Brandeis University, Waltham, United States.ORCID https://orcid.org/0000-0002-6555-8289
Jesse B HopkinsBiophysics Collaborative Access Team (BioCAT), Department of Physics, Illinois Institute of Technology, Chicago, United States.ORCID https://orcid.org/0000-0001-8554-8072
Maxwell B WatkinsBiophysics Collaborative Access Team (BioCAT), Department of Biology, Illinois Institute of Technology, Chicago, United States.ORCID https://orcid.org/0000-0003-4559-2049
Salvatore LaRussaDepartment of Biochemistry, Brandeis University, Waltham, United States.
Suhaily Caban-PenixDepartment of Biochemistry, Brandeis University, Waltham, United States.ORCID https://orcid.org/0009-0007-6512-5399
Logan A CalderoneDepartment of Biochemistry, Brandeis University, Waltham, United States.ORCID https://orcid.org/0000-0002-0960-3831
Niels BradshawDepartment of Biochemistry, Brandeis University, Waltham, United States.ORCID https://orcid.org/0000-0002-6845-4717

Funding

The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
GENETIC AND BIOCHEMICAL MECHANISMS OF REGULATIONT32GM007122 · NIGMS · BRANDEIS UNIVERSITY · PI LOVETT, SUSAN THOMAS · 1985 to 2020
$7.5M
Macromolecular Structure, Dynamics, and MechanismT32GM135126 · NIGMS · BRANDEIS UNIVERSITY · PI JEFF GELLES, Douglas Lowell Theobald · 2020 to 2026
$2.1M
Advanced Pixel Array Detector for Time-Resolved SAXS and Fiber DiffractionS10OD018090 · OD · ILLINOIS INSTITUTE OF TECHNOLOGY · PI IRVING, THOMAS C · 2014 to 2014
$529k
Brandeis University Startup FundsNIGMS NIH HHS P30 GM138395NIGMS NIH HHS T32 GM007122NIGMS NIH HHS T32 GM135126NIH HHS P30 GM138395NIH HHS S10 OD018090NIH HHS T32 GM007122NIH HHS T32 GM135126
6 · The paper itself

Abstract

The General Stress Response promotes survival of bacteria in adverse conditions, but how sensor proteins transduce species-specific signals to initiate the response is not known. The serine/threonine phosphatase RsbU initiates the General Stress Response in

Indexed as

Bacillus subtilisBacterial ProteinsStress, PhysiologicalGene Expression Regulation, BacterialProtein BindingProtein MultimerizationSignal TransductionBacterial ProteinsbiochemistryB. subtilischemical biologycoiled coilinfectious diseasemicrobiologyPPM phosphataseSAXSsigma factorstress response

Identifiers

PMID40478890
PMCPMC12143880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.