ArticleProceedings of the National Academy of Sciences of the United States of America2025
Endogenous competition and the underrealized reproduction of infectious diseases.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Scientific inquiry about the transmissibility of infectious diseases is largely based on the basic reproduction number ([Formula: see text]) and its derivations. This paper describes a mechanism overlooked in most conventional analyses, in which a disease can endogenously "compete" with itself when multiple infectious individuals race to infect the same susceptible individual, thereby reducing the effective reproductive rate. Utilizing an empirically calibrated network epidemiological model of wild-type COVID-19 diffusion in its early pandemic, we show that the mechanism would be expected to reduce its reproductive rate by an average of 39%. Simulation experiments further identify different types of endogenous competition mechanisms and their relative effect sizes. We highlight the incorporation of endogenous competition mechanism as a necessary step in realistically modeling the reproduction process of infectious diseases.
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