Observational studyPloS one2025
Impact of self-perceived discomfort in critically ill patients on the occurrence of psychiatric symptoms in post-intensive care syndrome (PICS): A prospective observational study.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Acute Respiratory Failure Survivors' Perspectives on Patient-Centered Communication: A Mixed Methods Study.Critical care explorations · 2026Observational
- Health-Related Quality of Life and Mobility Levels in ICU Survivors with Heel Pressure Ulcer: An Observational Study.Nursing reports (Pavia, Italy) · 2026Article
- The Hidden Burden After Critical Illnesses: A Systematic Review of Psychological Outcomes and Their Associated Factors Among ICU Survivors (2021-2025).Journal of multidisciplinary healthcare · 2026Review
- Health-related quality of life trajectories one year after COVID-19-induced ARDS: A secondary analysis of the CONFIDENT trial.Annals of intensive care · 2026Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMental health impairments after intensive care unit (ICU) discharge include anxiety, depression, and post-traumatic stress disorder [PTSD], forming part of the post-intensive care syndrome (PICS). We assessed the effects of discomfort on the occurrence of psychiatric symptoms as a part of PICS.
methodsThis prospective observational study conducted from September 2022 to June 2023 included all patients aged ≥ 18 years who survived an ICU stay of ≥3 days. To assess patient discomfort during the ICU stay, we used the Inconforts des Patients de REAnimation (IPREA) questionnaire. The primary outcome was the occurrence of anxiety, depression, or PTSD after ICU discharge. Secondary outcomes were the quality of life in ICU survivors and the clinical impression of physicians and psychologists to predict post-ICU psychiatric symptoms.
resultsOf the 173 patients included initially, 109 were finally analysed. An IPREA score ≥ 13 was strongly associated with an increased risk of post-ICU psychiatric symptoms (odds ratio: 3.8, 95% confidence interval: 1.4-10.3, p = 0.008). The patients with post-ICU psychiatric symptoms had a reduced quality of life. The clinical impression of physicians and psychologists at ICU discharge for the risk of psychiatric symptoms 3 months after the ICU stay was not selective.
conclusionsSelf-perceived discomfort in ICU survivors was the most predictive factor of the development of post-ICU psychiatric symptoms.
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