Evidence map›Paper›PMID 40478810›Full record

ArticleLung cancer management2025

Lung cancer screening in limited resource regions: the 3rd Brazilian Early Lung Cancer Trial (BRELT3/mobile ProPulmão).

Ricardo Sales Dos Santos, Ricardo G Figueiredo, Juliana P Franceschini, Cesar Augusto de Araújo Neto, Almério de Souza Machado Júnior, Bruno Hochhegger, Mario Claudio Ghefter, Ulisses Amancio Pereira Neto, Petrucio Abrantes Sarmento, Igor Barbosa Ribeiro and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung cancer management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Ricardo Sales Dos SantosInstituto Senai de Inovação em Sistemas Avançados de Saúde - Universidade SENAI CIMATEC, Salvador, Brazil.
Ricardo G FigueiredoPrograma de Pós-graduação em Saúde Coletiva, Universidade Estadual de Feira de Santana, Feira de Santana, Brazil.
Juliana P FranceschiniInstituto Propulmão, Salvador, Brazil.ORCID 0000-0002-6166-0235
Cesar Augusto de Araújo NetoInstituto Propulmão, Salvador, Brazil.
Almério de Souza Machado JúniorInstituto Propulmão, Salvador, Brazil.
Bruno HochheggerDepartment of Radiology, University of Florida, Gainesville, FL, USA.
Mario Claudio GhefterThoracic Surgery, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Ulisses Amancio Pereira NetoInstituto Propulmão, Salvador, Brazil.
Petrucio Abrantes SarmentoInstituto Propulmão, Salvador, Brazil.
Igor Barbosa RibeiroInstituto Propulmão, Salvador, Brazil.
Daniel Augusto Xavier CarvalhoInstituto Propulmão, Salvador, Brazil.
Felipe S PassosInstituto Propulmão, Salvador, Brazil.ORCID 0009-0001-7381-2806
Caio Santos HolandaInstituto Propulmão, Salvador, Brazil.
Marcel Samuel Blech HamaouiThoracic Surgery, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Gustavo Borges da Silva TelesDepartment of Diagnostic Imaging, Diagnóstico das Américas - DASA, São Paulo, Brazil.
Carolina Alves NevesDepartment of Diagnostic Imaging, Sabin Diagnóstico e Saúde, Salvador, Brazil.
Helena Alves Costa PereiraDepartment of Diagnostic Imaging, Diagnóstico das Américas - DASA, São Paulo, Brazil.
Jackline Pereira LetoDiagnóstico das Américas - DASA, Salvador, Brazil.
Adelmo de Souza Machado NetoFaculdade de Medicina Zarns, Salvador, Brazil.
Audrey Cabral Ferreira de OliveiraPrograma de Pós-graduação em Pesquisa Clínica e Translacional, Salvador, Brazil.
Fernando Nunes Galvão de OliveiraOncology, Oncoclinicas, Salvador, Brazil.
Clarissa MathiasOncology, Oncoclinicas, Salvador, Brazil.
César Garcia MachadoHospital Santa Izabel, Salvador, Brazil.
Josiane Dantas Viana BarbosaInstituto Senai de Inovação em Sistemas Avançados de Saúde - Universidade SENAI CIMATEC, Salvador, Brazil.
Marine Oliveira Barbosa SantosInstituto Senai de Inovação em Sistemas Avançados de Saúde - Universidade SENAI CIMATEC, Salvador, Brazil.
Crislaine Gomes da SilvaClinical Research Organization, Centro Universidade SENAI-CIMATEC, Salvador, Brazil.
Mariana Moreira da SilvaPrograma de Pós-graduação em Pesquisa Clínica e Translacional, Salvador, Brazil.
Lila Teixeira de AraújoClinical Research Organization, Centro Universidade SENAI-CIMATEC, Salvador, Brazil.
Álvaro A CruzProAR Foundation, Salvador, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo describe tomographic findings in a high-risk lung cancer population in resource-limited Brazilian areas, quantify pulmonary nodules and lung cancer frequency, analyze challenges in lung cancer screening within the Brazilian public health system, assess lung function in individuals with moderate or severe emphysema, and evaluate the role of community health agents in recruiting high-risk populations.

methodsThis is a prospective, single-arm, longitudinal observational study involving individuals aged 50-80 years, current or former smokers with a smoking history of at least 20 pack-years, undergoing low-dose computed tomography (LDCT) with a 12-month follow-up. Screening results are classified according to Lung-RADS v2022 standards, with those rated as 3 or 4 undergoing further diagnostic assessments. The study aims to demonstrate the feasibility and effectiveness of lung cancer screening in socially vulnerable populations within resource-limited settings, providing essential insights to reduce mortality and improve health outcomes.

conclusionsThe findings will assist the development of policies on lung cancer screening in the public health system. The study's dissemination plan includes a website, social media, and participation in scientific conferences.

Indexed as

biopsycommunity health agentsearly detectionLDCTlung cancerpulmonary nodulerisk factorsScreening

Identifiers

PMID40478810
PMCPMC12147508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.