Evidence map›Paper›PMID 40478631›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2025

Visualization of the Fetal Corpus Callosum in Routine Second Trimester Screening Ultrasound Examinations.

Shehani Fernando, Ilona Lavender, Peter Coombs, Keith Van Haltren, Paul Lombardo, Melinda Goodyear, Daniel L Rolnik

Abstract read
In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shehani FernandoDepartment of Medical Imaging, Monash Health, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-9088-7271
Ilona LavenderDepartment of Medical Imaging, Monash Health, Melbourne, Victoria, Australia.
Peter CoombsDepartment of Medical Imaging, Monash Health, Melbourne, Victoria, Australia.
Keith Van HaltrenDepartment of Medical Imaging, Monash Health, Melbourne, Victoria, Australia.
Paul LombardoDepartment of Medical Imaging and Radiation Sciences, Monash University, Melbourne, Victoria, Australia.
Melinda GoodyearSchool of Rural Health, Monash University, Melbourne, Victoria, Australia.
Daniel L RolnikDepartment of Obstetrics and Gynaecology, Women's and Newborn, Monash Health, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe primary aim of this study was to determine the visualization rate of the corpus callosum (CC) in the mid-sagittal plane of ultrasound examinations performed between 18 and 22 weeks' gestation. The secondary aims were to compare this rate to that achieved 5 years earlier at the same center; assess the need for transvaginal ultrasound; identify fetal head positions most favorable for sagittal CC assessment; and evaluate the impact of maternal body mass index (BMI) and gestational age on CC visualization.

methodsA retrospective analysis of images from second trimester screening examinations of singleton pregnancies performed between January 2019 and June 2019 was undertaken. The mid-sagittal image of the CC was scored on a scale from 0 to 4, with one point assigned for the visualization of each anatomical part. A score of 4 indicated complete visualization, a score of 1 to 3 was considered partial visualization, and a score of 0 represented nonvisualization. The chi-squared test was used to compare the visualization rates to those achieved 5 years earlier and previously reported by our group.

resultsA total of 999 second trimester screening examinations were included in the study. Complete CC visualization significantly improved from 71.3% at initial protocol implementation and training to 92.1% in the current study (P < .001). A transvaginal approach was required in 4.4% of cases. The craniocaudal fetal head position had the highest success rate (98.2%) for CC visualization. The odds of nonvisualization of the CC were 2.6 times higher before 20 weeks (7.4%) than at or after 20 weeks (3.0%) (odds ratio = 2.63, 95% confidence interval [1.20-5.76], P = .012). Higher maternal BMI (≥30.0 kg/m

conclusionComplete visualization of the CC in the mid-sagittal plane is achievable in routine second trimester morphology ultrasound examinations. Improvement in the quality of imaging is possible with a standardized protocol and training.

Indexed as

Corpus CallosumPregnancy Trimester, SecondUltrasonography, PrenatalAdultFemaleGestational AgeHumansPregnancyRetrospective Studiescallosal dysgenesiscorpus callosumobstetric ultrasoundscreeningsecond trimestersonography

Identifiers

PMID40478631
PMCPMC12421946

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.