Evidence map›Paper›PMID 40478590›Full record

ArticleTranslational vision science & technology2025

Evolution of Visual Field Defects After Occipital Stroke: A Quantitative Analysis.

Elizabeth L Saionz, Matthew R Cavanaugh, Brent A Johnson, Donald Harrington, Geoffrey K Aguirre, Krystel R Huxlin

Abstract read
In one paragraph

Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. From error to evidence: blindsight in the making†.Cerebral cortex (New York, N.Y. : 1991) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth L SaionzFlaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, NY, USA.
Matthew R CavanaughFlaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, NY, USA.
Brent A JohnsonDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA.
Donald HarringtonDepartment of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA.
Geoffrey K AguirreDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Krystel R HuxlinFlaum Eye Institute and Center for Visual Science, University of Rochester, Rochester, NY, USA.

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI MICHELE RUCCI · 1985 to 2026
$17.5M
University of Rochester Mentoring Environment: Nurturing Training Opportunities in Research (UR-MENTOR)T32GM007356 · NIGMS · UNIVERSITY OF ROCHESTER · PI O'BANION, M. KERRY · 1985 to 2023
$15.1M
VISUAL SCIENCET32EY007125 · NEI · UNIVERSITY OF ROCHESTER · PI Krystel R Huxlin, Duje Tadin · 1990 to 2026
$7.1M
Vision recovery in cortical blindnessR01EY027314 · NEI · UNIVERSITY OF ROCHESTER · PI MARISA CARRASCO, Krystel R Huxlin · 2017 to 2026
$5.3M
NRSA Training CoreTL1TR002000 · NCATS · UNIVERSITY OF ROCHESTER · PI THAKAR, JUILEE, VAN WIJNGAARDEN, EDWIN · 2016 to 2024
$4.1M
NCATS NIH HHS TL1 TR002000NEI NIH HHS P30 EY001319NEI NIH HHS R01 EY027314NEI NIH HHS T32 EY007125NIGMS NIH HHS T32 GM007356
6 · The paper itself

Abstract

Purpose: To quantitatively re-evaluate the natural progression of homonymous visual defects in occipital stroke patients using metrics derived from automated perimetry. Methods: We performed a retrospective chart review of stroke patients with homonymous hemianopia who underwent repeated, monocular Humphrey perimetry using the 24-2 SITA standard pattern from 2011 to 2019 at a large US academic medical center. Reliable tests in either eye were analyzed to track progression of the perimetric mean deviation (PMD) and deficit area before and after a temporal boundary set at 6 ± 1 months post-stroke. Results: Out of 532 patients diagnosed with homonymous hemianopia, repeated Humphrey tests meeting reliability criteria were available for 73 individuals, who ranged from 0 to 2986 days post-stroke. Over 77% of these patients experienced spontaneous perimetric improvements in the subacute post-stroke period (<6 months), much larger for partial than complete visual field defects. In the chronic period (>6 months), perimetric measurements were stable overall, but spontaneous changes > ±1 dB in PMD were seen in about half of the cohort. Conclusions: Quantitative analysis of Humphrey perimetry confirmed prior reports of prevalent spontaneous improvements early after occipital stroke in adults. Though much less frequent, improvements as well as worsening of the visual defects still occurred in the chronic period. Translational Relevance: Our quantification of perimetric changes over time after occipital stroke provides an empirical and methodological basis for future studies aiming to better understand and prognostically manage patient expectations regarding recovery. It also provides a necessary benchmark against which to contrast the impact of restorative therapies being developed for this condition.

Indexed as

HemianopsiaOccipital LobeStrokeVisual FieldsAdultAgedDisease ProgressionFemaleHumansMaleMiddle AgedRetrospective StudiesVisual Field Tests

Identifiers

PMID40478590
PMCPMC12155684

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.