Evidence map›Paper›PMID 40478516›Full record

ArticleMolecular neurobiology2025

Ginsenoside Rg1 Downregulates miR-9-5p Expression to Modulate SIRT1-Mediated Mitochondrial Dysfunction and Ameliorate Alzheimer's Disease.

Yunliang Wang, Xiangyun Sun, Biao He, Shaowen Yu

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yunliang Wang *College of Physical Education, AnHui Normal University, Wuhu, 241003, P.R. China.
Xiangyun Sun *The Department of Geriatrics, the First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Jinghu District, No. 2 West Zheshan Road, Anhui Province, Wuhu, 241001, P.R. China. sunxy2_wh@163.com.
Biao HeCollege of Physical Education, AnHui Normal University, Wuhu, 241003, P.R. China.
Shaowen YuDepartment of Basic Medicine, Wannan Medical College, Wuhu, 241003, P.R. China.

Funding

Anhui Provincial Natural Science Foundation: Research on the molecular mechanism of PGC-1α mediated exercise against Alzheimer's disease 2108085MH265
6 · The paper itself

Abstract

This study aimed to investigate the mechanism of ginsenoside Rg1 in Alzheimer's disease (AD) via miR-9-5p/SIRT1-mediated mitochondrial function. The cognitive function of AD mice was assessed by Morris water maze experiment. The histopathological changes in the CA1 region were observed by H&E staining. TUNEL staining combined with the neuronal marker NeuN was used to detect neuronal apoptosis in hippocampal tissues. Aβ

Indexed as

Alzheimer DiseaseDown-RegulationGinsenosidesMicroRNAsMitochondriaSirtuin 1Amyloid beta-PeptidesAnimalsApoptosisAutophagyCell LineHippocampusMaleMiceMice, Inbred C57BLPeptide FragmentsAmyloid beta-Peptidesginsenoside Rg1GinsenosidesMicroRNAsMIRN9 microRNA, mousePeptide FragmentsSirt1 protein, mouseSirtuin 1Alzheimer diseaseGinsenoside Rg1MiR-9-5pMitochondrial autophagyMitochondrial dysfunctionSIRT1

Identifiers

PMID40478516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.