Evidence map›Paper›PMID 40478420›Full record

ArticleIn vitro cellular & developmental biology. Animal2025

Enhancement of 5-fluorouracil efficacy in colorectal cancer cells through thymidylate synthase inhibition by sodium propionate.

Nayeon Kim, Yeoreum Lee, Taerim Kim, Jiyun Kim, Changwon Yang

Abstract read
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In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nayeon KimDepartment of Science Education, Ewha Womans University, Seoul, 03760, Republic of Korea.
Yeoreum LeeDepartment of Science Education, Ewha Womans University, Seoul, 03760, Republic of Korea.
Taerim KimDepartment of Science Education, Ewha Womans University, Seoul, 03760, Republic of Korea.
Jiyun KimDepartment of Science Education, Ewha Womans University, Seoul, 03760, Republic of Korea.
Changwon YangDepartment of Science Education, Ewha Womans University, Seoul, 03760, Republic of Korea. cyang@ewha.ac.kr.ORCID http://orcid.org/0000-0001-5326-9124

Funding

Ministry of Education 2024S1A5C3A03046593
6 · The paper itself

Abstract

5-Fluorouracil (5-FU) is a cornerstone chemotherapeutic agent commonly employed in colorectal cancer (CRC) treatment. Prolonged use of 5-FU can trigger drug resistance, primarily through the upregulation of thymidylate synthase (TS). Consequently, strategies targeting TS suppression could enhance 5-FU's therapeutic potential in resistant CRC cases. Short-chain fatty acids (SCFAs), derived from the fermentation of dietary fibers by gut microbiota, are implicated in various disease mechanisms, including cancer. Among SCFAs, sodium butyrate (NaB) is known to inhibit TS expression, reduce CRC cell viability, and promote apoptosis. However, the potential of sodium propionate (NaP), another SCFA, to exhibit similar effects remains under investigation. This study reveals that NaP, when combined with 5-FU, synergistically decreases CRC cell survival and enhances apoptosis. Furthermore, NaP counteracts the 5-FU-induced upregulation of TS, amplifying its inhibitory effects on drug-resistant CRC cells. These results suggest that NaP may serve as an effective adjunct in improving the therapeutic outcomes of 5-FU-based CRC treatments.

Indexed as

Colorectal NeoplasmsFluorouracilPropionatesThymidylate SynthaseApoptosisCell Line, TumorCell SurvivalDrug Resistance, NeoplasmDrug SynergismGene Expression Regulation, NeoplasticHumansFluorouracilPropionatessodium propionateThymidylate SynthaseApoptosisColon cancerDrug resistanceShort-chain fatty acid

Identifiers

PMID40478420

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.