Evidence map›Paper›PMID 40478386›Full record

SynthesisNeurosurgical review2025

Factors influencing the efficacy of surgical repair for spontaneous middle cranial fossa CSF leaks: a systematic review and meta-analyses.

Jordan M Rasmussen, Kautilya R Patel, Daniel L Surdell, Patrick J Opperman, Geoffrey Casazza, Anne K Maxwell, Cindy M Schmidt, Harlan R Sayles, Mithun G Sattur

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Risk Reduction of Recurrent Cerebrospinal Fluid Leaks With Postoperative Intracranial Pressure Management: A Systematic Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Pooled it
  2. Spontaneous cerebrospinal fluid leaks and encephaloceles: multi-institutional collaborative retrospective analysis of 468 cases with special focus on recurrent cases.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jordan M RasmussenSchool of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Kautilya R PatelDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, USA.ORCID http://orcid.org/0000-0002-2900-7818
Daniel L SurdellDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, USA.
Patrick J OppermanDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, USA.
Geoffrey CasazzaDepartment of Otolaryngology- Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NE, USA.
Anne K MaxwellDepartment of Otolaryngology- Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NE, USA.
Cindy M SchmidtMcGoogan Health Sciences Library, University of Nebraska Medical Center, Omaha, NE, USA.
Harlan R SaylesDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, NE, USA.
Mithun G SatturDepartment of Neurosurgery, University of Nebraska Medical Center, Omaha, NE, USA. msattur@unmc.edu.ORCID http://orcid.org/0000-0002-2404-3780

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spontaneous middle cranial fossa cerebrospinal fluid (CSF) leaks can be treated surgically by middle cranial fossa (MCF), transmastoid (TM), or combined approaches. Efficacy of these approaches and the factors influencing CSF leak recurrence rates need further clarity. A literature search was conducted across EMBASE, MEDLINE, Scopus, and the Cochrane Library. Case reports, non-English articles, and studies with pediatric patients alone were excluded. Proportional meta-analysis was used to estimate the CSF leak recurrence rates. Influence of associated comorbidities and adjuvant treatment measures was studied. Forty-five studies with 990 patients were included. 52% patients were females. Mean BMI was 35.8 kg/m². IIH and OSA were noted in 23.6% (8 studies) and 49.5% (6 studies) of patients, respectively. Mean opening pressure (8 studies) was 24.29 cm H

Indexed as

Cerebrospinal Fluid LeakCranial Fossa, MiddleNeurosurgical ProceduresFemaleHumansTreatment OutcomeIdiopathic intracranial hypertensionMiddle cranial fossaObesityObstructive sleep apneaSkull baseSpontaneous cerebrospinal fluid leakSurgical repair

Identifiers

PMID40478386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.