Evidence map›Paper›PMID 40478374›Full record

ArticleInternational urology and nephrology2025

Trends and outcomes in kidney retransplantation: a 2-decade longitudinal analysis.

Abolfazl Jamshidi, Janice Liu, Sajedeh Jadidi, Emily Harland, Mahmoudreza Moein, Reza Saidi

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Article in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Abolfazl JamshidiDivision of Transplant Services, Department of Surgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA.
Janice Liu *Division of Transplant Services, Department of Surgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA.
Sajedeh Jadidi *Division of Transplant Services, Department of Surgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA.
Emily Harland *Division of Transplant Services, Department of Surgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA.
Mahmoudreza MoeinDivision of Transplant Services, Department of Surgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA.
Reza SaidiDivision of Transplant Services, Department of Surgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA. SaidiR@upstate.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to evaluate kidney retransplantation outcomes to optimize patient care and reduce the risk of further retransplantation.

methodsWe conducted a retrospective longitudinal analysis of the Scientific Registry of Transplant Recipients (SRTR) database for kidney retransplants performed in the United States from January 2000 to May 2023. Patients were divided into subgroups based on transplant date and number of previous transplants. Outcomes were assessed by patient and allograft survival.

resultsA total of 34,230 patients were evaluated (12,224 in 2000-2011, 22,006 in 2012-2023). The proportion of DCD (donation after cardiac death) donors was significantly higher in 2012-2023 (21.3% vs. 8.8%, p < 0.001). Both patient and allograft survival improved in the more recent time frame (5-year survival: 84.8% vs. 83.7% for patients; 75.9% vs. 69.3% for allografts, p < 0.001). Allograft failure rates were higher with increasing retransplant attempts (5-year survival: 73.4% vs. 71.8% vs. 62.3% for first, second, and third + retransplants, p < 0.001). DGF increased failure risk (HR: 1.69 [1.60-1.79] in 2000-2011; HR: 1.79 [1.63-1.97] in 2012-2023), as did higher kidney donor profile index (KDPI) (HR: 1.96 [1.70-2.26] in 2000-2011; HR: 2.34 [1.82-3.01] in 2012-2023). Allograft thrombosis contribution as an etiology for failure increased (OR: 2.94 [2.20, 3.92] for the first; OR: 3.13 [1.58, 6.79] for the second + retransplants).

conclusionKidney retransplant outcomes have improved, but each successive transplant has a poorer prognosis. Careful patient selection and risk assessment, especially regarding high KDPI and DGF (delayed graft function), are critical. Further investigation is needed into the rising proportion of allograft thrombosis.

Indexed as

Kidney TransplantationReoperationAdultFemaleGraft SurvivalHumansLongitudinal StudiesMaleMiddle AgedRegistriesRetrospective StudiesTime FactorsTreatment OutcomeUnited StatesAllograft survivalKidney transplantationLong-term outcomesPatient survivalPrognosisRetransplantation

Identifiers

PMID40478374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.