Evidence map›Paper›PMID 40478315›Full record

ArticleCell regeneration (London, England)2025

Mongolian medicine Eerdun-Wurile promotes myocardial regeneration by regulating MVDA in zebrafish.

Xianghui Chen, Xiaoting Li, Jiajun Sun, Yufeng Lin, Yuanhao Li, Xuehao Lv, Rui Zhao, Xinyue Gu, Wenxuan Wang, Yabin Xie and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell regeneration (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xianghui Chen *Department of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Xiaoting Li *Department of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Jiajun Sun *Department of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Yufeng Lin *Department of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Yuanhao LiDepartment of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Xuehao LvDepartment of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Rui ZhaoSchool of Public Health, Baotou Medical College, Baotou, Inner Mongolia, China.
Xinyue GuDepartment of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Wenxuan WangDepartment of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Yabin XieInner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Wei XieInner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Rengui BadeInner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Shuyuan JiangInner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Xiaolei LiuInner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Bo ZouDepartment of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Yannan BiDepartment of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Guo ShaoInner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China.
Haihua BaiAffiliated Hospital of Inner Mongolia Minzu University, Tongliao, 028000, China.
Wei ZhuInner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China. zhuwei200289@163.com.
Xiaoe JiaDepartment of Basic Medicine and Forensic Medicine, Baotou Medical College, Baotou, Inner Mongolia, 014040, China. evangeline2004@163.com.ORCID http://orcid.org/0000-0002-5127-471X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI) is a leading cause of death and disability worldwide. The promotion of myocardial regeneration is a promising therapeutic strategy for acute MI. Using a zebrafish ventricular ablation system, we found that the Mongolian traditional medicine Eerdun-Wurile (EW) promotes myocardial regeneration in zebrafish. EW treatment significantly accelerated proliferation of myocardial cells and improved cardiac function. Transcriptome sequencing revealed a significant decrease in mevalonate diphosphate decarboxylase a (mvda) expression in the metronidazole-induced ventricular ablation group, whereas mvda expression was restored in the EW group. mvda knockdown using morpholino oligonucleotides reversed the EW-mediated myocardial regeneration, whereas mvda overexpression enhanced the regenerative ability. In conclusion, EW may promote zebrafish myocardial regeneration, accelerate myocardial cell proliferation, and improve cardiac function by upregulating mvda expression. Our data partially revealed the molecular mechanism by which EW promotes myocardial regeneration and repair, and provides experimental data and novel insights for advancing MI treatment.

Indexed as

CardiomyocytesMVDAProliferationRegeneration and repair

Identifiers

PMID40478315
PMCPMC12143999

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.