ArticleInternational urogynecology journal2025
Expressions of IGF-1, pAKT, and pS6 in Uterosacral Ligaments of Patients with Pelvic Organ Prolapse.
Article in International urogynecology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Insulin-like growth factor receptor signaling in physiology and disease.Signal transduction and targeted therapy · 2026Review
- Comment on "Expressions of IGF-1, pAKT, and pS6 in Uterosacral Ligaments of Patients with Pelvic Organ Prolapse".International urogynecology journal · 2026Article
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5 authors.
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Abstract
introduction and hypothesisThe objective was to investigate the expressions and significance of IGF-1, pAKT, pS6, and type I and type III collagens in uterosacral ligaments of patients with pelvic organ prolapse (POP).
methodsA total of 38 patients with POP who underwent hysterectomy or pelvic floor reconstruction were selected as the POP group. Another 38 patients who underwent hysterectomy owing to nonpelvic floor dysfunction were selected as the control group. The POP quantitative staging scores of the two groups were III-IV and 0-I respectively. The histological manifestations of the abandoned uterosacral ligament tissues near the cervix were evaluated using hematoxylin-eosin staining and Masson staining. The expressions of IGF-1, plGF-1R, pAKT, pS6, and type I and type III collagen fibers were detected using immunohistochemistry and Western blotting.
resultsHematoxylin-eosin and Masson staining showed that the number of POP constituent fibrocytes decreased, the arrangement was disordered, and the distribution of collagen fibers was sparse compared with the control group. Immunohistochemical analysis showed that the expressions of IGF-1, pIGF-1R, pAKT , pS6, and type I and type III collagen in uterosacral ligament tissues of the POP group significantly decreased. Western blotting demonstrated that the expressions of IGF-1, pIGF-1R, pAKT, pS6, and type I and type III collagen in the POP group significantly decreased.
conclusionThe expressions of IGF-1, pAKT, pS6, and type I and type III collagen decreased in the uterosacral ligament tissues of POP patients, and the IGF-1/AKT/mTORC1 signaling pathway regulated by IGF-1 may be related to the occurrence of POP.
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