Evidence map›Paper›PMID 40478269›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Clinical Frailty Scale versus Geriatric-8 in predicting quality of life among older adults receiving curative cancer treatment.

Wen Yang Goh, Hui Min Tan, Hui Lin Teo, Elise K Y Vong, Francis C H Ho, Ming Yann Lim, Allyn Y M Hum

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04513977 (Geriatric Oncology SuPportive Clinic for ELderly), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04513977 narecruitingnot on this map

Geriatric Oncology SuPportive Clinic for ELderly

TypeinterventionalSponsorGoh Wen YangRan2020 to 2025Enrolled200ConditionsCancer, FrailtyArmsGeriatric Oncology Supportive Clinic
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen Yang GohDepartment of Palliative Medicine, Tan Tock Seng Hospital, Jalan Tan Tock Seng, Annex 2, Level 3, 11, Novena, 308433, Singapore. Wen_Yang_Goh@ttsh.com.sg.ORCID http://orcid.org/0000-0003-1990-2138
Hui Min TanDepartment of Geriatric Medicine, Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore, Singapore.
Hui Lin TeoDepartment of Medical Oncology, Tan Tock Seng Hospital, Singapore, Singapore.
Elise K Y VongDepartment of Medical Oncology, Tan Tock Seng Hospital, Singapore, Singapore.
Francis C H HoDepartment of Radiation Oncology, National University Cancer Institute, Singapore, Singapore.
Ming Yann LimDepartment of of Otorhinolaryngology and Head and Neck Surgery, Tan Tock Seng Hospital, Singapore, Singapore.
Allyn Y M HumDepartment of Palliative Medicine, Tan Tock Seng Hospital, Jalan Tan Tock Seng, Annex 2, Level 3, 11, Novena, 308433, Singapore.

Funding

The Palliative Care Centre for Excellence in Research and Education PalC-RG-19/P004
6 · The paper itself

Abstract

introductionFrailty assessment is fundamental to geriatric oncology (GO), with GO guidelines endorsing Geriatric-8 (G8) as a frailty screening tool. Although the Clinical Frailty Scale (CFS) is widely used in geriatrics, no studies have examined its quality of life (QoL) utility in GO. We compare CFS and G8 in their ability to predict quality of life among older adults receiving curative cancer treatment. PATIENTS AND

methodsOne hundred thirteen patients (age ≥ 65 years) were recruited from a 2000-bed university-affiliated tertiary hospital between August 2020 and May 2024. Patient demographics, CFS and G8 were collected. The EORTC QLQ-ELD14 and the EQ5D-VAS were measured at start of treatment, and monthly after for 3 months. Patients were stratified by CFS or G8 and compared with QoL at various time points controlled for age, gender, BMI, and G8.

resultsUsing CFS, frail subjects had poorer QoL in the EORTC QLQ-ELD14 subscales for mobility (p < 0.001), joint stiffness (p < 0.001), maintaining purpose (p = 0.03), and EQ5D-VAS (p = 0.003) at start of treatment; mobility (p = 0.004 and p = 0.009) and EQ5D-VAS (p = 0.03 and p = 0.009) scores at one and 2 months. QoL scores between groups were similar at 3 months. Using G8, only EQ5D-VAS was poorer for frail subjects at start of treatment (p = 0.02). CFS remained a significant indicator of poor QoL controlled for age, gender, BMI, and G8.

conclusionCFS is a significant and better indicator of poor QoL in older adults with cancer receiving curative treatment compared to G8. Further research should explore implementation of supportive care for specific QoL deficit detected by CFS.

trial registrationNCT04513977; Date 2020-08-14.

Indexed as

FrailtyGeriatric AssessmentNeoplasmsQuality of LifeAgedAged, 80 and overFemaleFrail ElderlyHumansMaleCurative cancer treatmentFrailty assessmentGeriatric oncologyQuality of lifeSupportive care

Identifiers

PMID40478269

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.