Evidence map›Paper›PMID 40478227›Full record

ArticleeLife2025

Upstream open reading frames buffer translational variability during

Yuanqiang Sun, Yuange Duan, Peixiang Gao, Chenlu Liu, Kaichun Jin, Shengqian Dou, Wenxiong Tang, Hong Zhang, Jian Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuanqiang Sun *State Key Laboratory of Gene Function and Modulation Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing, China.ORCID https://orcid.org/0009-0007-6967-2234
Yuange Duan *State Key Laboratory of Gene Function and Modulation Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing, China.ORCID https://orcid.org/0000-0003-2311-9859
Peixiang GaoState Key Laboratory of Gene Function and Modulation Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing, China.
Chenlu LiuState Key Laboratory of Gene Function and Modulation Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing, China.ORCID https://orcid.org/0000-0002-8993-0145
Kaichun JinState Key Laboratory of Gene Function and Modulation Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing, China.
Shengqian DouEye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Beijing, China.
Wenxiong TangState Key Laboratory of Gene Function and Modulation Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing, China.
Hong ZhangCollege of Ecology, Lanzhou University, Lanzhou, China.
Jian LuState Key Laboratory of Gene Function and Modulation Research, Center for Bioinformatics, School of Life Sciences, Peking University, Beijing, China.ORCID https://orcid.org/0000-0002-4409-1667

Funding

Ministry of Science and Technology of the People's Republic of China 2022YFE0132000National Natural Science Foundation of China 32070597Natural Science Foundation of Beijing 5212006Yunnan Provincial Science and Technology Project at Southwest United Graduate School 202302A0370006
6 · The paper itself

Abstract

Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown. Upstream open reading frames (uORFs) are widespread

Indexed as

Drosophila melanogasterEvolution, MolecularOpen Reading FramesProtein BiosynthesisAnimalsDrosophila ProteinsHomeodomain ProteinsHumansRNA, MessengerTrans-Activatorsbcd protein, DrosophilaDrosophila ProteinsHomeodomain ProteinsRNA, MessengerTrans-Activatorsbicoiddrosophila melanogasterdrosophila simulansevolutionary biologygeneticsgenomicshumansTASEP modelingtranslational regulationtranslation evolutionuORF

Identifiers

PMID40478227
PMCPMC12143884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.