ReviewJournal of congenital cardiology2021
Down syndrome and congenital heart disease: perioperative planning and management.
Review in Journal of congenital cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Immune dysregulation in children with Down syndrome: clinical implications and emerging therapies.Current opinion in rheumatology · 2026Review
- Risk Factors for low Cardiac Output Syndrome in Children less than 6 years old Undergoing Ventricular Septal Defect Closure: a Retrospective Cohort Study.Pediatric cardiology · 2026Article
- Treatment Options Offered to Infants with Single Ventricle Physiology and Genetic Aneuploidy: A Survey of US Pediatric Intensivists, Cardiologists, and Cardiothoracic Surgeons.Pediatric cardiology · 2026Article
- Experiences of caregivers and healthcare providers regarding health services for children with Down syndrome in Karachi; Pakistan.PLOS global public health · 2026Article
- B-Cell Acute Lymphoblastic Leukemia in a Child with Down Syndrome and High-Risk Genomic Lesions.Current issues in molecular biology · 2025Article
- Article
- The Impact of Down Syndrome on Perioperative Anesthetic Management and Outcomes in Infants Undergoing Isolated Ventricular Septal Defect Closure.Diagnostics (Basel, Switzerland) · 2025Article
- Hygienic behaviors and use of dental care in patients with genetic syndromes.Scientific reports · 2024Article
- Trisomy 21 and Congenital Heart Disease: Impact on Health and Functional Outcomes From Birth Through Adolescence: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2024Review
- Down syndrome and postoperative hemodynamics in patients undergoing surgery for congenital cardiac communications.Scientific reports · 2024Article
- Nationwide hospitalizations of patients with down syndrome and congenital heart disease over a 15-year period.European journal of pediatrics · 2024Article
- Safety and Efficacy of Surgical and Percutaneous Cardiac Interventions for Adults With Down Syndrome.Mayo Clinic proceedings. Innovations, quality & outcomes · 2024Article
- Development of pulmonary hypertension remains a major hurdle to corrective surgery in Down syndrome.World journal of cardiology · 2024Article
- Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.Science translational medicine · 2024Article
- Long-Term Non-Congenital Cardiac and Renal Complications in Down Syndrome: A Study of 32,936 Patients.Children (Basel, Switzerland) · 2023Article
- [Congenital heart disease in Down's syndrome].Archivos de cardiologia de Mexico · 2023Article
- Endocrine Disorders in a Newborn with Heterozygous Galactosemia, Down Syndrome and Complex Cardiac Malformation: Case Report.Medicina (Kaunas, Lithuania) · 2023Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately 50% of newborns with Down syndrome have congenital heart disease. Non-cardiac comorbidities may also be present. Many of the principles and strategies of perioperative evaluation and management for patients with congenital heart disease apply to those with Down syndrome. Nevertheless, careful planning for cardiac surgery is required, evaluating for both cardiac and noncardiac disease, with careful consideration of the risk for pulmonary hypertension. In this manuscript, for children with Down syndrome and hemodynamically significant congenital heart disease, we will summarize the epidemiology of heart defects that warrant intervention. We will review perioperative planning for this unique population, including anesthetic considerations, common postoperative issues, nutritional strategies, and discharge planning. Special considerations for single ventricle palliation and heart transplantation evaluation will also be discussed. Overall, the risk of mortality with cardiac surgery in pediatric patients with Down syndrome is no more than the general population, except for those with functional single ventricle heart defects. Underlying comorbidities may contribute to postoperative complications and increased length of stay. A strong understanding of cardiac and non-cardiac considerations in children with Down syndrome will help clinicians optimize perioperative care and long-term outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.