Evidence map›Paper›PMID 40476838›Full record

SynthesisThe journal of spinal cord medicine2026

Robotic-assisted gait training for spinal cord injury neuropathic pain: A systematic review.

Conor White, Samantha Klus, Wing Hai Ho, Lily Barrett, Orlaith Doherty, Olive Lennon

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in The journal of spinal cord medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Conor WhiteSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.ORCID 0000-0003-1524-3673
Samantha KlusSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Wing Hai HoSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Lily BarrettSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Orlaith DohertySchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Olive LennonSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextNeuropathic pain (NP), can be a debilitating consequence of spinal cord injury. Robotic-assisted gait training (RAGT) is an effective rehabilitation tool, but emerging evidence suggests it may prove an effective treatment for NP post-SCI.

objectiveThis systematic review aims to synthesize the available evidence examining RAGT for pain reduction post-SCI, focusing on NP.

methodsSix databases were searched from inception to February 18th 2025, using search strings addressing: SCI and RAGT. No date or study type restrictions applied. Studies with SCI populations, delivering RAGT and measuring pain outcomes were included. Meta-analyses were conducted for pain intensity, pain interference (PI) and HRQoL outcomes. Certainty of evidence (COE) was assessed using GRADE criteria.

resultsThirty two studies (n = 567) (6 RCTs) met eligibility criteria. No RCT mandated pain as an inclusion criterion. Meta-analysis of 6 RCTs (n = 174) identified no effect for RAGT over other interventions for outcomes of overall pain intensity (SMD = 0.03 [-0.40, 0.46]; P = 0.90), non-specified pain-type intensity (SMD = 0.08 [-0.39, 0.55]; P = 0.74) and in one RCT reporting NP intensity (SMD = -0.46 [-1.61, 0.70]; P = 0.44). Meta-analysis identified no difference between RAGT and comparators for outcomes of HRQoL (3 RCTs (n = 69): SMD = 0.15 [-0.33,0.62]; P = 0.54) and PI (2 RCTs (n = 53): SMD = -0.1 [-0.64,0.44]; P = 0.71). Very-low COE for pain intensity & PI and low COE for HRQoL were assigned.

conclusionsVery limited studies and inconclusive evidence supports RAGT for the reduction of NP post-SCI. Future RCTs of RAGT that recruit patients with moderate-to-severe NP at baseline are required.

Indexed as

Exercise TherapyGaitNeuralgiaRoboticsSpinal Cord InjuriesHumansExoskeletonNeuropathic painNeurorehabilitationRobotic assisted gait trainingSpinal cord injury

Identifiers

PMID40476838
PMCPMC13295081

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.