ArticleDiabetes & vascular disease research
Early diagnosis value of lncRNA SNHG14 combined with miR-493-5p in gestational diabetes mellitus and its correlation with pregnancy outcome.
Article in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Letter to editor: Comments on "Early diagnosis value of lncRNA SNHG14 combined with miR-493-5p in gestational diabetes mellitus and its correlation with pregnancy outcome".Diabetes & vascular disease researchArticle
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5 authors.
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Abstract
BackgroundTo evaluate the diagnostic value of lncRNA SNHG14 and miR-493-5p in gestational diabetes mellitus (GDM).MethodsThis study consisted of 128 GDM patients and 125 healthy controls. Dual luciferase reporter assay detected binding of lncRNA SNHG14 and miR-493-5p. ROC was applied to evaluate the diagnostic value of lncRNA SNHG14 and miR-493-5p for GDM. Independent factors affecting GDM were evaluated using logistic regression analysis. The role of lncRNA SNHG14, miR-493-5p in pregnancy outcome in GDM patients was assessed by chi-square tests.ResultsLncRNA SNHG14 has a target-binding relationship with miR-493-5p. LncRNA SNHG14 was significantly higher in GDM patients, while miR-493-5p was significantly lower; both were independent risk factors for GDM development. Blood glucose indices (fasting, 1 h and 2 h postprandial) were positively correlated with lncRNA SNHG14 and negatively correlated with miR-493-5p in GDM patients. LncRNA SNHG14 in combination with miR-493-5p increased the diagnostic efficiency for GDM. LncRNA SNHG14 was significantly associated with neonatal weight and neonatal jaundice. MiR-493-5p was significantly associated with neonatal jaundice.ConclusionLncRNA SNHG14 in combination with miR-493-5p may be an early diagnostic marker of GDM. LncRNA SNHG14 and miR-493-5p are associated with adverse pregnancy outcomes (macrosomia, neonatal jaundice) in patients with GDM.
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