Evidence map›Paper›PMID 40476722›Full record

ReviewJournal of bacteriology2025

Applying the brakes to transcription: regulation of gene expression by RNA polymerase pausing.

Oshadhi T Jayasinghe, Paul Babitzke

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. RfaH licenses RNA polymerase for long-range transcription.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Oshadhi T JayasingheDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
Paul BabitzkeDepartment of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-2481-1062

Funding

Regulation of transcription elongationR01GM098399 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BABITZKE, PAUL L · 2012 to 2024
$3.6M
Post-transcription Initiation Control of Gene ExpressionR35GM153190 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PAUL L BABITZKE · 2024 to 2026
$1.3M
NIGMS NIH HHS R01 GM098399NIGMS NIH HHS R35 GM153190NIH HHS GM098399NIH HHS GM153190
6 · The paper itself

Abstract

Transcription by RNA polymerase is punctuated by transient pausing events. Pausing provides additional time for proper RNA folding and binding of regulatory factors to the paused transcription elongation complex or the nascent RNA. Depending on the organism and the genomic context, the general transcription elongation factors NusA and NusG stimulate or suppress pausing. Both

Indexed as

Bacillus subtilisDNA-Directed RNA PolymerasesEscherichia coliGene Expression Regulation, BacterialTranscription, GeneticBacterial ProteinsEscherichia coli ProteinsMycobacterium tuberculosisPeptide Elongation FactorsTranscription FactorsBacterial ProteinsDNA-Directed RNA PolymerasesEscherichia coli ProteinsNusG protein, E coliPeptide Elongation FactorsTranscription FactorsNusANusGriboswitchRNA polymerase pausingtranscriptiontranscriptional regulationtranscription attenuation

Identifiers

PMID40476722
PMCPMC12288461

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.