ArticleJournal of medical virology2025
Genetic and Inflammatory Signatures Associated With Worse Prognosis in Hospitalized Patients With Severe SARS-CoV-2 Infection With and Without Diabetes.
Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Severe acute respiratory syndrome coronavirus 2 (SAR-CoV-2) presents with a diverse symptomology, ranging from asymptomatic to severe disease, but the mechanism of risk factors such as diabetes remains unelucidated. The current retrospective cohort study of 182 patients, with and without COVID-19 and diabetes, analyzed leftover blood specimens for RNA sequencing and chemokine/cytokine, ACE2/DPP-IV concentrations. After analysis, 14 223 genes had sufficient hits; 18 genes and 431 genes were differentially expressed between patients with and without COVID-19 and patients with and without diabetes, respectively. Both analyses had differentially expressed five genes, GRASP, KRT8, MYZAP, PRKG1, and SMIM24. DPP-IV concentrations were statistically lower in COVID-19 patients versus non-COVID-19, but no significant differences in chemokine/cytokine expression and ACE2 concentrations were detected. This study provides insight into altered gene expression patterns in individuals with COVID-19 with and without diabetes mellitus and highlights potential markers for severe disease and pathways for treatment targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.