Evidence map›Paper›PMID 40476640›Full record

ArticleSICOT-J2025

Analgesia considerations in orthopaedic surgery: the role of magnesium sulfate infusions.

Thomas J Papadimos, Scott M Pappada, Jacob Alexander, Pavlos Altsitzioglou, Theodosis Saranteas, Sebastien Lustig, Andreas F Mavrogenis

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in SICOT-J, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas J PapadimosDepartment of Anesthesiology, Surgery, and Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606-3390, USA.
Scott M PappadaDepartment of Anesthesiology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606-3390, USA.
Jacob AlexanderDepartment of Orthopaedic Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43606-3390, USA.
Pavlos AltsitzioglouFirst Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens 11527, Greece.
Theodosis SaranteasSecond Department of Anesthesiology, National and Kapodistrian University of Athens, School of Medicine, Athens 11527, Greece.
Sebastien LustigOrthopaedics Surgery and Sports Medicine Department, FIFA Medical Center of Excellence, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon University Hospital, 103 Grande Rue de la Croix-Rousse, 69004 Lyon, France - Univ Lyon, Claude Bernard Lyon 1 University, IFSTTAR, LBMC UMR_T9406, 25 Avenue François Mitterand, 69622 Lyon, France.
Andreas F MavrogenisFirst Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens 11527, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orthopaedic surgical operations are associated with significant post-operative pain, often managed with opioids, which carry risks of adverse effects and dependency. Magnesium sulfate, a NMDA receptor antagonist with analgesic and muscle relaxant properties, has emerged as a potential adjunct to improve pain control and reduce opioid consumption in orthopaedic procedures. Current evidence supports magnesium sulfate as a valuable adjunct in orthopaedic pain management, particularly in reducing opioid consumption and enhancing muscle relaxation. However, heterogeneity in study design, administration protocols, and patient populations warrants cautious interpretation. Monitoring for side effects such as hypotension and respiratory depression remains essential. Further high-quality, standardized trials are needed to optimize dosing strategies and confirm long-term benefits.

Indexed as

Magnesium sulfateOrthopaedic surgeryPain

Identifiers

PMID40476640
PMCPMC12143129

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.