Observational studyTherapeutic advances in respiratory disease
The correlation between the level of therapy adherence and inhalation technique in children with uncontrolled asthma using a smart inhaler: the IMAGINE study.
Observational study in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Compliance with outpatient nebulization inhalation therapy in preschool children: implication for nursing care.BMC nursing · 2026Article
- Behavioral Phenotypes of Inhaler Technique and Adherence in COPD: A Cross-Sectional Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Guided Inhalation via Electronic Monitoring in Children With Uncontrolled Asthma (the IMAGINE Study): Randomized Controlled Trial.JMIR pediatrics and parenting · 2025Article
- Budesonide/formoterol for pediatric asthma: bridging the gap between evidence and practice in Maintenance and Reliever Therapy.Frontiers in medicine · 2025Article
- Telemedicine in the management of chronic respiratory diseases: lessons learned and future perspectives.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is a chronic condition with a high health and social burden in children. Although many well-studied effective therapies are available, because of suboptimal adherence and inhalation technique, asthma in children remains frequently uncontrolled. It is often assumed that adherence and technique are highly correlated items, but this assumption has not been thoroughly validated.
objectiveThis trial evaluates the correlation between adherence and inhalation technique and the association of patient-related factors with these two important parameters.
designObservational phase I of the IMproving Adherence by Guiding INhalation via Electronic monitoring (IMAGINE) study, a three-phased Randomized Controlled Trial (RCT) in children with uncontrolled asthma.
methodsThe observational phase I of the IMAGINE study was designed to determine the correlation between adherence and inhalation technique in pediatric subjects with uncontrolled asthma. During this observational study phase, adherence and inhalation technique were measured with a smart add-on device called Respiro
resultsOf the 34 enrolled subjects, 6-18 years old, suffering from moderate to severe uncontrolled asthma, 32 successfully completed phase I. No significant correlation between adherence and inhalation technique was observed (
conclusionOur findings demonstrated no correlation between therapy adherence and inhalation technique, suggesting that these should be regarded as distinct and frequent pitfalls of inhaled medication use.We observed that inhalation technique was significantly associated with ER visits, rescue medication use, age, and height, while good adherence correlated with ER visits. Recognizing these factors allows pediatricians to identify risk profiles for poor inhalation technique and poor adherence, enabling more targeted and personalized interventions.
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