Evidence map›Paper›PMID 40476556›Full record

ArticleMolecular medicine reports2025

Otubain 2 stabilizes TNF‑receptor associated factor 3 to accelerate bone fracture healing.

Li Zhang, Jialiang Guo, Shan Feng, Yue Zheng, Haixu Wang, Huijie Ma, Wei Chen, Yingze Zhang, Zhiyong Hou

Abstract read
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li ZhangDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Jialiang GuoDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Shan FengDepartment of General Medicine, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Yue ZhengDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Haixu WangDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Huijie MaDepartment of Physiology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
Wei ChenDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Yingze ZhangDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Zhiyong HouDepartment of Orthopaedic Surgery, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased incidence of traumatic fracture markedly effects the quality of life of patients. Using a rat model of femur fracture, the present study aimed to investigate the effects of otubain 2 (OTUB2), a deubiquitinating enzyme, on bone fracture healing. Bone marrow mesenchymal stem cells (BMSCs) were harvested from the marrow cavity of rat femurs and tibiae and subsequently subjected to osteogenic differentiation

Indexed as

Deubiquitinating EnzymesFracture HealingFractures, BoneTNF Receptor-Associated Factor 3AnimalsCell DifferentiationDisease Models, AnimalFemoral FracturesMaleMesenchymal Stem CellsOsteogenesisRatsRats, Sprague-DawleyUbiquitinationDeubiquitinating EnzymesTNF Receptor-Associated Factor 3bone fracture healingfracture callusotubain 2TNF‑receptor associated factor 3ubiquitin

Identifiers

PMID40476556
PMCPMC12174901

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.