ArticleJournal of global health2025
Impact of lifestyle factors on adult-onset asthma in genetically high-risk individuals.
Article in Journal of global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Asthma is a heterogeneous disease influenced by genetic and environmental factors. Identifying high-risk individuals for developing asthma is a major goal of primary prevention. Recent studies have reported that genetic factors can predict high-risk groups for various diseases. However, the understanding of genetically high-risk individuals for adult-onset asthma, which could be potential targets for preventive interventions, remains limited. Using a polygenic risk score (PRS), we identified a group of individuals at a genetically high risk for adult-onset asthma and examined their characteristics, as well as the degree of risk reduction through lifestyle factors. Methods: Using the asthma PRS provided by the UK Biobank, we identified a genetically high-risk group among unrelated White British individuals, including those with adult-onset asthma and a control group. We analysed the association between asthma-related lifestyle factors and adult-onset asthma in the high-risk group. Additionally, we conducted Kaplan-Meier analysis to investigate the cumulative incidence of adult-onset asthma by age of onset according to genetic risk and lifestyle status. Results: The high-risk group for adult-onset asthma had a 2.26 times higher risk of developing asthma compared to the average-risk group. Within the high-risk group, lifestyle factors, such as obesity-related traits, stress, insomnia, and snoring, were significantly associated with adult-onset asthma. Among individuals in the high-risk group, adhering to a favourable lifestyle can reduce the lifetime risk of adult-onset asthma by up to 40% compared to those with an unfavourable lifestyle. Conclusions: Based on this study, we suggest that the PRS can identify individuals at high risk of developing adult-onset asthma. Furthermore, our findings indicate that individuals with a genetically high risk may reduce their disease risk through appropriate lifestyle modifications, emphasising their potential to benefit significantly from primary prevention strategies. However, as this study is cross-sectional and assumes that lifestyle factors have remained unchanged, further prospective studies are required to validate these findings.
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