Evidence map›Paper›PMID 40476513›Full record

ArticleEmerging microbes & infections2025

Development of an oral gut-targeted rabies virus-like particles (RVLPs) vaccine with mucosal immune adjuvant LTB via delivering of localized-release microparticles.

Jinping Niu, Zhangting Zhao, Tong Zhang, Qingwei Liu, Liyao Huang, Shipo Li, Haipeng Liu, Shaowen Yu, Linfeng Li, Hao Jia and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jinping NiuState Key Laboratory of Bioreactor engineering, East China University of Science and Technology, Shanghai, People's Republic of China.
Zhangting ZhaoState Key Laboratory of Bioreactor engineering, East China University of Science and Technology, Shanghai, People's Republic of China.
Tong ZhangShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic of China.
Qingwei LiuShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic of China.
Liyao HuangShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic of China.
Shipo LiState Key Laboratory of Bioreactor engineering, East China University of Science and Technology, Shanghai, People's Republic of China.
Haipeng LiuState Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, People's Republic of China.
Shaowen YuSchool of Mathematics, East China University of Science and Technology, Shanghai, People's Republic of China.
Linfeng LiState Key Laboratory of Bioreactor engineering, East China University of Science and Technology, Shanghai, People's Republic of China.
Hao JiaSchool of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.ORCID 0000-0003-1856-6013
Wenyun ZhengShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic of China.
Feng YangSchool of Pharmacy, Naval Medical University, Shanghai, People's Republic of China.
Xingyuan MaState Key Laboratory of Bioreactor engineering, East China University of Science and Technology, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rabies, a fatal zoonotic infectious diseases caused by rabies virus (RABV) infection, still has a high incidence with no effective cure in many Asian countries, even though numerous commercial vaccines have been administered for decades. One of the most important reasons is the neglected that main reservoirs of RABV, such as many stray and wild animals, are inaccessible for effective vaccination, especially in natural wilderness environments. In this study, we developed a highly effective gut-targeted oral rabies vaccine (ORV), which containing the immunoadjuvant LTB by targeted administration of microparticles with local release in the intestine. Based on the virus like particles (RVLPs) were assembled by RABV glycoprotein (RVGP) and matrix protein (RVMP), the enterically released microparticles ELPGA MPs loaded with RVLPs and djuvant LTB (RVLPs + LTB/EPLGA MPs) were prepared and demonstrated the ability of intestinal targeting which released in a pH-dependent manner. Subsequently,

Indexed as

Adjuvants, ImmunologicRabiesRabies VaccinesRabies virusVaccines, Virus-Like ParticleAdministration, OralAnimalsAntibodies, ViralFemaleImmunoglobulin GMiceMice, Inbred BALB CAdjuvants, ImmunologicAntibodies, ViralImmunoglobulin GRabies VaccinesVaccines, Virus-Like Particlelocalized-release microparticlesLTB B subunit of heat-labile toxin (LTB)mucosal immune vaccinesOral gut-targetedPLGA/Eudradit microparticle (EPLGA MPs)rabies virus-like particles (RVLPs)

Identifiers

PMID40476513
PMCPMC12172084

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.