Evidence map›Paper›PMID 40476282›Full record

ArticleJournal of radiosurgery and SBRT2025

Tumor-targeted Gamma Knife radiosurgery in patients with trigeminal neuralgia secondary to benign tumors.

Roger Murayi, Jordan C Petitt, Robert D Winkelman, Pablo F Recinos, Samuel T Chao, Erin S Murphy, Pranay Soni, Gene H Barnett, John H Suh, Varun R Kshettry

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of radiosurgery and SBRT, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roger MurayiDepartment of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Jordan C PetittDepartment of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Robert D WinkelmanDepartment of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Pablo F RecinosDepartment of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Samuel T ChaoDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Erin S MurphyDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Pranay SoniDepartment of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Gene H BarnettDepartment of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
John H SuhDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Varun R KshettryDepartment of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Secondary trigeminal neuralgia (TN) is often associated with benign meningiomas and schwannomas. For patients who are unable to undergo surgical resection, Gamma Knife radiosurgery (GKRS) is a well-established alternative for tumor control. There is limited data on the pain outcomes in these patients undergoing tumor-targeted GKRS. Methods: Patients receiving tumor-targeted GKRS for a benign tumor causing secondary TN between 2005 and 2021 were identified. The Barrow Neurological Institute (BNI) pain score was documented at baseline and over the course of clinical follow-up. The study endpoint was defined as either last documented follow-up or date of additional pain procedure. Results: Seventeen patients were identified with 12 meningiomas (71%), 4 vestibular schwannomas (24%), and 1 trigeminal schwannoma (6%). Patients received either a single fraction of 12-13 Gy in 14 patients (82%) or 25 Gy in 5 fractions for 3 patients (18%). At a mean time to study endpoint of 29.5 months, 6 patients (35%) were pain free. Median time to BNI pain improvement was 4.6 months post-GKRS. One patient (6%) experienced new onset facial numbness. After the study endpoint, five patients (29%) underwent at least one subsequent balloon compression procedure for pain control. Mean total follow-up time was 61.9 months. Conclusion: For patients with secondary TN due to benign lesions who are poor candidates for surgical resection, tumor-targeted GKRS has a modest effect on pain outcomes. Complication rates are also comparatively very low.

Indexed as

facial painmeningiomaradiosurgerysecondary trigeminal neuralgiavestibular schwannoma

Identifiers

PMID40476282
PMCPMC12136688

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.