Evidence map›Paper›PMID 40476255›Full record

ArticleNPJ dementia2025

Multiplex digital spatial profiling identifies subregion dependent targeted proteome changes across variants of dementia.

MacKenzie L Bolen, Kelly B Menees, Marla Gearing, Jingjing Gong, Yuqi Ren, Andrea R Merchak, Melissa E Murray, Zachary T McEachin, Malú Gámez Tansey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ dementia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Emerging technologies in the spatial proteomics landscape.Analytical and bioanalytical chemistry · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

MacKenzie L BolenCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL USA.
Kelly B MeneesCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL USA.
Marla GearingDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA USA.
Jingjing GongNanoString Technologies Inc, Seattle, WA USA.
Yuqi RenNanoString Technologies Inc, Seattle, WA USA.
Andrea R MerchakCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL USA.
Melissa E MurrayDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL USA.
Zachary T McEachinLaboratory of Translational Cell Biology, Emory University School of Medicine, Atlanta, GA USA.
Malú Gámez TanseyCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL USA.

Funding

The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI Amy D Rodriguez · 2020 to 2026
$29.0M
Role of central and peripheral immune crosstalk in FTD-Grn neurodegenerationRF1NS128800 · NINDS · UNIVERSITY OF FLORIDA · PI FINKBEINER, STEVEN M, TANSEY, MARIA DE LOURDES GAMEZ · 2022 to 2022
$2.4M
Role of Gut Inflammation and Immunity on Proteostasis, Noradrenergic Degeneration and AD riskRF1AG057247 · NIA · UNIVERSITY OF FLORIDA · PI NEISH, ANDREW S, TANSEY, MARIA DE LOURDES GAMEZ · 2017 to 2017
$1.6M
NIA NIH HHS P30 AG066511NIA NIH HHS RF1 AG057247NINDS NIH HHS RF1 NS128800
6 · The paper itself

Abstract

Frontotemporal lobar degeneration (FTLD) is the leading cause of dementia in patients under the age of 65. Even in a single anatomical region, there is variance within pathological protein deposition within the FTLD spectrum, which drives difficulty in post-mortem clinicopathological diagnoses. We spatially multiplexed the proteome geography at two levels of the cortex and the subcortical white matter in patients with various types of dementia (Alzheimer's disease, C9orf72, MAPT also referred to as FTLD-tau, FTLD-TDP, FTLD-GRN;

Indexed as

Diagnostic markersImagingMolecular neuroscienceNeurological disordersNeuroscience

Identifiers

PMID40476255
PMCPMC12133586

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.