ReviewRSC advances2025
Amide linked chalcone derivatives, a promising class of compounds with versatile biological effects.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Exploration of novel hydroxamic acid-based candidates integrating chalcone scaffold cap as multitarget HDAC inhibitors: design, anti-prostatic cancer assessment,Journal of enzyme inhibition and medicinal chemistry · 2026Article
- Camptothecin Nanoformulations: Recent Advances in Preparation, Bioactivities, and Clinical Perspectives.Annals of biomedical engineering · 2026Review
- Article
- Investigation on the Cytotoxicity of Hydroxycinnamic and Hydroxybenzoic Acid-Based Natural Antioxidant Conjugated Terpyridine Analogues toward Triple-Negative Breast Cancer.ACS medicinal chemistry letters · 2026Article
- Novel pyrazole-oxadiazole-chalcone/oxime hybrids as dual EGFR/VEGFR-2 inhibitors with promising anticancer potential: a comprehensive cytotoxicity evaluation, mechanistic insights and SAR analysis.Molecular diversity · 2026Article
- Design, synthesis, and biological evaluation of novel chalcone derivatives: integrating molecular docking withRSC advances · 2026Article
- Cardamonin as a potential anticancer agent: Preclinical insights and clinical implications.World journal of clinical oncology · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chalcone-linked acetamide derivatives represent a unique class of compounds with a broad spectrum of biological activities. Various synthetic methods for chalcones are reviewed, emphasizing their efficiency. These derivatives exhibited potent antiproliferative properties, functioning as inhibitors of key targets such as EGFR, topoisomerase I and II, ABCG2, caspase proteins, and histone deacetylase (HDAC), as well as inhibiting tubulin polymerization. The structure-activity relationships (SAR) pertinent to their anticancer activity are elucidated. In addition to their antiproliferative effects, these compounds display significant antimicrobial activities against a variety of bacterial and fungal pathogens. Their antiviral potential is also highlighted, with capabilities to inhibit critical viral enzymes and pathways. The antiprotozoal properties of chalcone-linked acetamide derivatives underscore their efficacy against protozoan infections. Furthermore, these derivatives possess strong anti-inflammatory and antioxidant activities, contributing to their overall therapeutic potential. By exploring these diverse biological activities, these compounds present significant opportunities for the development of novel therapeutic agents overcoming various medical challenges.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.