Evidence map›Paper›PMID 40476182›Full record

ArticleStem cells international2025

miR-1275 Delivered via Mesenchymal Stem Cell-Derived Extracellular Vesicles Regulates ER-Phagy Through AXIN2 in Nucleus Pulposus Cells.

Zhiwu Dong, Hailong Zhang, Wenwei Yang, Keliang Huang, Xin Zhang, Lianxiang Xing, Ying Zhang, Kewen Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhiwu DongDepartment of Laboratory Medicine, Shanghai Second People's Hospital, Shanghai 200011, China.ORCID https://orcid.org/0000-0002-3792-9556
Hailong ZhangDepartment of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301, Yanchang Road, Shanghai 200072, China.ORCID https://orcid.org/0000-0003-2171-622X
Wenwei YangDepartment of Laboratory Medicine, Shanghai Second People's Hospital, Shanghai 200011, China.ORCID https://orcid.org/0009-0002-3227-2783
Keliang HuangDepartment of Laboratory Medicine, Shanghai Second People's Hospital, Shanghai 200011, China.ORCID https://orcid.org/0009-0009-7304-0074
Xin ZhangDepartment of Laboratory Medicine, Shanghai Second People's Hospital, Shanghai 200011, China.ORCID https://orcid.org/0009-0004-9186-9402
Lianxiang XingDepartment of Laboratory Medicine, Shanghai Second People's Hospital, Shanghai 200011, China.ORCID https://orcid.org/0009-0004-1417-6602
Ying ZhangDepartment of Laboratory Medicine, Shanghai Second People's Hospital, Shanghai 200011, China.ORCID https://orcid.org/0009-0003-1606-2003
Kewen ZhaoKey Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-3135-1607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration (IDD) is a major contributor to low back pain, a prevalent and debilitating condition. Nucleus pulposus (NP) cells are essential for maintaining disc homeostasis, and their dysfunction plays a crucial role in IDD development. This study aimed to explore the potential role of miR-1275, delivered via mesenchymal stem cell-derived extracellular vesicles (MSCs-EVs), in IDD pathogenesis and to elucidate the underlying molecular mechanisms through

Indexed as

apoptosisAXIN2ER-phagyER-stressintervertebral disc degenerationmiR-1275

Identifiers

PMID40476182
PMCPMC12140824

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.